Detailed information of TA system TA212090

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2135345..2135644
• Replicon: chromosome
• Accession: NZ_CP080553
• Organism: Staphylococcus aureus strain HL18380

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: JMO11_RS10695
• Protein ID: WP_011447039.1
• Coordinates: 2135468..2135644 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2135345..2135400 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO11_RS10655	2130676..2130936	+	261	WP_001791826.1	hypothetical protein	-
JMO11_RS10660	2130989..2131339	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
JMO11_RS10665	2132024..2132473	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
JMO11_RS10670	2132568..2132903	-	336	Protein_2070	SH3 domain-containing protein	-
JMO11_RS10675	2133553..2134044	-	492	WP_000919350.1	staphylokinase	-
JMO11_RS10680	2134235..2134990	-	756	WP_000861038.1	CHAP domain-containing protein	-
JMO11_RS10685	2135002..2135256	-	255	WP_000611512.1	phage holin	-
JMO11_RS10690	2135308..2135415	+	108	WP_001791821.1	hypothetical protein	-
-	2135337..2135476	+	140	NuclAT_0	-	-
-	2135337..2135476	+	140	NuclAT_0	-	-
-	2135337..2135476	+	140	NuclAT_0	-	-
-	2135337..2135476	+	140	NuclAT_0	-	-
-	2135345..2135400	+	56	-	-	Antitoxin
JMO11_RS10695	2135468..2135644	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
JMO11_RS10700	2135794..2136090	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
JMO11_RS10705	2136148..2136435	-	288	WP_001040261.1	hypothetical protein	-
JMO11_RS10710	2136482..2136634	-	153	WP_001153681.1	hypothetical protein	-
JMO11_RS10715	2136624..2140409	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2130989..2186937	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T212090 WP_011447039.1 NZ_CP080553:c2135644-2135468 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T212090 NZ_CP106964:284214-284489 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGCTGGAGCAACTGTTTAAAATCCCTGTGCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAGGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT212090 NZ_CP080553:2135345-2135400 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin