Detailed information of TA system TA212087

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1974414..1974596
• Replicon: chromosome
• Accession: NZ_CP080553
• Organism: Staphylococcus aureus strain HL18380

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JMO11_RS09705
• Protein ID: WP_001801861.1
• Coordinates: 1974414..1974509 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1974537..1974596 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO11_RS09665	1970074..1970700	+	627	Protein_1910	hypothetical protein	-
JMO11_RS09670	1970741..1971085	+	345	WP_000627551.1	DUF3969 family protein	-
JMO11_RS09675	1971183..1971734	+	552	WP_000414205.1	hypothetical protein	-
JMO11_RS09680	1971952..1972593	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
JMO11_RS09685	1972707..1972892	-	186	WP_000809857.1	hypothetical protein	-
JMO11_RS09690	1972894..1973070	-	177	WP_000375476.1	hypothetical protein	-
JMO11_RS09695	1973081..1973464	-	384	WP_000070811.1	hypothetical protein	-
JMO11_RS09700	1974068..1974211	-	144	WP_001549059.1	transposase	-
JMO11_RS09705	1974414..1974509	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1974537..1974596	-	60	-	-	Antitoxin
JMO11_RS09710	1974632..1974733	+	102	WP_001791893.1	hypothetical protein	-
JMO11_RS09715	1974711..1974887	-	177	Protein_1920	transposase	-
JMO11_RS09720	1975081..1975458	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1948388..2007685	59297

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T212087 WP_001801861.1 NZ_CP080553:1974414-1974509 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T212087 NZ_CP106930:10206-10511 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTTATCCCCCTGGCCAGCGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTCATTGGGGAAGAAGTG
GCCGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT212087 NZ_CP080553:c1974596-1974537 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin