Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 931514..931928 Replicon chromosome
Accession NZ_CP080553
Organism Staphylococcus aureus strain HL18380

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMO11_RS04590 Protein ID WP_001826875.1
Coordinates 931514..931765 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMO11_RS04595 Protein ID WP_000028424.1
Coordinates 931755..931928 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO11_RS04540 (926853) 926853..927524 + 672 WP_016028251.1 putative HNHc nuclease -
JMO11_RS04545 (927634) 927634..928293 - 660 WP_016028252.1 hypothetical protein -
JMO11_RS04550 (928339) 928339..929109 + 771 WP_000190226.1 conserved phage C-terminal domain-containing protein -
JMO11_RS04555 (929119) 929119..929892 + 774 WP_000803028.1 ATP-binding protein -
JMO11_RS04560 (929886) 929886..930044 + 159 WP_000256589.1 hypothetical protein -
JMO11_RS04565 (930058) 930058..930279 + 222 WP_001123681.1 DUF3269 family protein -
JMO11_RS04570 (930290) 930290..930694 + 405 WP_000049798.1 DUF1064 domain-containing protein -
JMO11_RS04575 (930699) 930699..930884 + 186 WP_016028253.1 DUF3113 family protein -
JMO11_RS04580 (930885) 930885..931253 + 369 WP_016028254.1 SA1788 family PVL leukocidin-associated protein -
JMO11_RS04585 (931257) 931257..931499 + 243 WP_000131389.1 SAV1978 family virulence-associated passenger protein -
JMO11_RS04590 (931514) 931514..931765 + 252 WP_001826875.1 DUF1024 family protein Toxin
JMO11_RS04595 (931755) 931755..931928 + 174 WP_000028424.1 hypothetical protein Antitoxin
JMO11_RS04600 (931929) 931929..932210 + 282 WP_000454993.1 hypothetical protein -
JMO11_RS04605 (932211) 932211..932372 + 162 WP_000889683.1 hypothetical protein -
JMO11_RS04610 (932387) 932387..932914 + 528 WP_220338214.1 dUTPase -
JMO11_RS04615 (932951) 932951..933157 + 207 WP_016028256.1 DUF1381 domain-containing protein -
JMO11_RS04620 (933154) 933154..933327 + 174 WP_000595257.1 transcriptional activator RinB -
JMO11_RS04625 (933328) 933328..933690 + 363 WP_000383791.1 hypothetical protein -
JMO11_RS04630 (933691) 933691..933837 + 147 WP_000989961.1 hypothetical protein -
JMO11_RS04635 (933852) 933852..934271 + 420 WP_000058634.1 transcriptional regulator -
JMO11_RS04640 (934458) 934458..934898 + 441 WP_009560332.1 terminase small subunit -
JMO11_RS04645 (934885) 934885..936162 + 1278 WP_009560330.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 892707..963864 71157


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9489.40 Da        Isoelectric Point: 3.9476

>T212086 WP_001826875.1 NZ_CP080553:931514-931765 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAIGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T212086 NZ_CP106929:c4308194-4307976 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT212086 WP_000028424.1 NZ_CP080553:931755-931928 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT212086 NZ_CP106929:c4308594-4308220 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References