Detailed information of TA system TA212082

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2586604..2586788
• Replicon: chromosome
• Accession: NZ_CP080552
• Organism: Staphylococcus aureus strain HL18807

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: JMO12_RS13045
• Protein ID: WP_000482652.1
• Coordinates: 2586681..2586788 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2586604..2586664 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO12_RS13030 (JMO12_002607)	2582059..2582190	-	132	WP_223197975.1	hypothetical protein	-
JMO12_RS13035 (JMO12_002608)	2582457..2584190	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
JMO12_RS13040 (JMO12_002609)	2584215..2585978	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2586604..2586664	+	61	-	-	Antitoxin
JMO12_RS13045 (JMO12_002610)	2586681..2586788	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
JMO12_RS13050 (JMO12_002611)	2586922..2587308	-	387	WP_000779360.1	flippase GtxA	-
JMO12_RS13055 (JMO12_002612)	2587576..2588718	+	1143	WP_001176863.1	glycerate kinase	-
JMO12_RS13060 (JMO12_002613)	2588778..2589437	+	660	WP_000831298.1	membrane protein	-
JMO12_RS13065 (JMO12_002614)	2589619..2590830	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JMO12_RS13070 (JMO12_002615)	2590953..2591426	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T212082 WP_000482652.1 NZ_CP080552:c2586788-2586681 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T212082 NZ_CP106929:c3511315-3510989 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT212082 NZ_CP080552:2586604-2586664 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin