Detailed information of TA system TA212081

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2561109..2561626
• Replicon: chromosome
• Accession: NZ_CP080552
• Organism: Staphylococcus aureus strain HL18807

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: JMO12_RS12910
• Protein ID: WP_000113265.1
• Coordinates: 2561109..2561375 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: JMO12_RS12915
• Protein ID: WP_000584499.1
• Coordinates: 2561375..2561626 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO12_RS12880 (JMO12_002577)	2556537..2557073	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
JMO12_RS12885 (JMO12_002578)	2557307..2558131	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
JMO12_RS12890 (JMO12_002579)	2558348..2558530	-	183	WP_000230292.1	hypothetical protein	-
JMO12_RS12895 (JMO12_002580)	2558614..2559081	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
JMO12_RS12900 (JMO12_002581)	2559267..2560814	-	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
JMO12_RS12905 (JMO12_002582)	2561003..2561074	-	72	Protein_2516	hypothetical protein	-
JMO12_RS12910 (JMO12_002583)	2561109..2561375	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
JMO12_RS12915 (JMO12_002584)	2561375..2561626	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JMO12_RS12920 (JMO12_002585)	2561791..2561871	-	81	WP_223197974.1	hypothetical protein	-
JMO12_RS12925 (JMO12_002586)	2561899..2562498	-	600	WP_000162810.1	DsbA family protein	-
JMO12_RS12930 (JMO12_002587)	2562517..2562879	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
JMO12_RS12935 (JMO12_002588)	2563134..2564384	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
JMO12_RS12940 (JMO12_002589)	2564481..2565212	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
JMO12_RS12945 (JMO12_002590)	2565209..2565928	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T212081 WP_000113265.1 NZ_CP080552:c2561375-2561109 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T212081 NZ_CP106929:3499482-3499655 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT212081 WP_000584499.1 NZ_CP080552:c2561626-2561375 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT212081 NZ_CP106929:3499158-3499454 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60