Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2561109..2561626 | Replicon | chromosome |
| Accession | NZ_CP080552 | ||
| Organism | Staphylococcus aureus strain HL18807 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | JMO12_RS12910 | Protein ID | WP_000113265.1 |
| Coordinates | 2561109..2561375 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | JMO12_RS12915 | Protein ID | WP_000584499.1 |
| Coordinates | 2561375..2561626 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO12_RS12880 (JMO12_002577) | 2556537..2557073 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| JMO12_RS12885 (JMO12_002578) | 2557307..2558131 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| JMO12_RS12890 (JMO12_002579) | 2558348..2558530 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| JMO12_RS12895 (JMO12_002580) | 2558614..2559081 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| JMO12_RS12900 (JMO12_002581) | 2559267..2560814 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| JMO12_RS12905 (JMO12_002582) | 2561003..2561074 | - | 72 | Protein_2516 | hypothetical protein | - |
| JMO12_RS12910 (JMO12_002583) | 2561109..2561375 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| JMO12_RS12915 (JMO12_002584) | 2561375..2561626 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| JMO12_RS12920 (JMO12_002585) | 2561791..2561871 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| JMO12_RS12925 (JMO12_002586) | 2561899..2562498 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| JMO12_RS12930 (JMO12_002587) | 2562517..2562879 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| JMO12_RS12935 (JMO12_002588) | 2563134..2564384 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| JMO12_RS12940 (JMO12_002589) | 2564481..2565212 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| JMO12_RS12945 (JMO12_002590) | 2565209..2565928 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T212081 WP_000113265.1 NZ_CP080552:c2561375-2561109 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T212081 NZ_CP106929:3499482-3499655 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT212081 WP_000584499.1 NZ_CP080552:c2561626-2561375 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT212081 NZ_CP106929:3499158-3499454 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|