Detailed information of TA system TA212075

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2002813..2002993
• Replicon: chromosome
• Accession: NZ_CP080552
• Organism: Staphylococcus aureus strain HL18807

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JMO12_RS09850
• Protein ID: WP_001801861.1
• Coordinates: 2002813..2002908 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2002936..2002993 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO12_RS09820 (JMO12_001966)	1997976..1998626	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
JMO12_RS09825 (JMO12_001967)	1998707..1999702	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
JMO12_RS09830 (JMO12_001968)	1999777..2000403	+	627	WP_000669024.1	hypothetical protein	-
JMO12_RS09835 (JMO12_001969)	2000444..2000785	+	342	WP_000627540.1	DUF3969 family protein	-
JMO12_RS09840 (JMO12_001970)	2000886..2001458	+	573	WP_000414216.1	hypothetical protein	-
JMO12_RS09845 (JMO12_001971)	2001656..2002668	-	1013	Protein_1952	IS3 family transposase	-
JMO12_RS09850 (JMO12_001972)	2002813..2002908	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2002936..2002993	-	58	-	-	Antitoxin
JMO12_RS09855 (JMO12_001973)	2003031..2003132	+	102	WP_001792025.1	hypothetical protein	-
JMO12_RS09860 (JMO12_001974)	2003110..2003271	-	162	Protein_1955	transposase	-
JMO12_RS09865 (JMO12_001975)	2003256..2003666	-	411	WP_001808705.1	IS21 family transposase	-
JMO12_RS09870 (JMO12_001976)	2004208..2005437	-	1230	WP_000072626.1	restriction endonuclease subunit S	-
JMO12_RS09875 (JMO12_001977)	2005430..2006986	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
JMO12_RS09880 (JMO12_001978)	2007150..2007284	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1997218..2029825	32607

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T212075 WP_001801861.1 NZ_CP080552:2002813-2002908 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T212075 NZ_CP106929:c2048892-2048557 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT212075 NZ_CP080552:c2002993-2002936 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin