Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1668438..1669017 | Replicon | chromosome |
| Accession | NZ_CP080552 | ||
| Organism | Staphylococcus aureus strain HL18807 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | JMO12_RS08190 | Protein ID | WP_001025401.1 |
| Coordinates | 1668772..1669017 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1668438..1668803 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO12_RS08150 (JMO12_001632) | 1665182..1665739 | - | 558 | WP_000645045.1 | DUF2815 family protein | - |
| JMO12_RS08155 (JMO12_001633) | 1665765..1666931 | - | 1167 | WP_000762525.1 | DUF2800 domain-containing protein | - |
| JMO12_RS08160 (JMO12_001634) | 1666928..1667290 | - | 363 | WP_000279445.1 | hypothetical protein | - |
| JMO12_RS08165 (JMO12_001635) | 1667305..1667628 | - | 324 | WP_000174995.1 | hypothetical protein | - |
| JMO12_RS08170 (JMO12_001636) | 1667707..1667868 | - | 162 | WP_015986189.1 | DUF1270 family protein | - |
| JMO12_RS08175 (JMO12_001637) | 1667880..1668143 | - | 264 | WP_044426023.1 | helix-turn-helix domain-containing protein | - |
| JMO12_RS08180 (JMO12_001638) | 1668168..1668383 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| JMO12_RS08185 (JMO12_001639) | 1668438..1668803 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| JMO12_RS08190 (JMO12_001640) | 1668772..1669017 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| JMO12_RS08195 (JMO12_001641) | 1669073..1669282 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| JMO12_RS08200 (JMO12_001642) | 1669272..1669415 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| JMO12_RS08205 (JMO12_001643) | 1669430..1669873 | - | 444 | WP_044414793.1 | hypothetical protein | - |
| JMO12_RS08210 (JMO12_001644) | 1669897..1670118 | - | 222 | WP_031887876.1 | DUF739 family protein | - |
| JMO12_RS08215 (JMO12_001645) | 1670279..1671049 | + | 771 | WP_031887877.1 | S24 family peptidase | - |
| JMO12_RS08220 (JMO12_001646) | 1671061..1671207 | + | 147 | WP_001049401.1 | hypothetical protein | - |
| JMO12_RS08225 (JMO12_001647) | 1671204..1671389 | + | 186 | WP_000109189.1 | hypothetical protein | - |
| JMO12_RS08230 (JMO12_001648) | 1671459..1671626 | + | 168 | WP_000705241.1 | hypothetical protein | - |
| JMO12_RS08235 (JMO12_001649) | 1671766..1672470 | + | 705 | WP_000440838.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| JMO12_RS08240 (JMO12_001650) | 1672681..1673886 | + | 1206 | WP_031766111.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | ebp | 1620372..1691511 | 71139 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T212072 WP_001025401.1 NZ_CP080552:c1669017-1668772 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T212072 NZ_CP106929:1200570-1200947 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGTTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGTTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 366 bp
>AT212072 NZ_CP080552:1668438-1668803 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
