Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2456485..2457002 | Replicon | chromosome |
| Accession | NZ_CP080551 | ||
| Organism | Staphylococcus aureus strain HL18840 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | JMO13_RS12245 | Protein ID | WP_000113262.1 |
| Coordinates | 2456485..2456751 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | JMO13_RS12250 | Protein ID | WP_000584499.1 |
| Coordinates | 2456751..2457002 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO13_RS12220 (2451908) | 2451908..2452444 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| JMO13_RS12225 (2452678) | 2452678..2453502 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| JMO13_RS12230 (2453719) | 2453719..2453901 | - | 183 | WP_000079142.1 | hypothetical protein | - |
| JMO13_RS12235 (2453988) | 2453988..2454455 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| JMO13_RS12240 (2454641) | 2454641..2456191 | - | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| JMO13_RS13960 (2456379) | 2456379..2456450 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| JMO13_RS12245 (2456485) | 2456485..2456751 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| JMO13_RS12250 (2456751) | 2456751..2457002 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| JMO13_RS12255 (2457167) | 2457167..2457247 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| JMO13_RS12260 (2457275) | 2457275..2457874 | - | 600 | WP_000162803.1 | DsbA family protein | - |
| JMO13_RS12265 (2457893) | 2457893..2458255 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| JMO13_RS12270 (2458510) | 2458510..2459760 | + | 1251 | WP_001012228.1 | FemA/FemB family glycyltransferase FmhA | - |
| JMO13_RS12275 (2459857) | 2459857..2460588 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| JMO13_RS12280 (2460585) | 2460585..2461304 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T212068 WP_000113262.1 NZ_CP080551:c2456751-2456485 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T212068 NZ_CP106929:571427-571603 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT212068 WP_000584499.1 NZ_CP080551:c2457002-2456751 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT212068 NZ_CP106929:571649-572065 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|