Detailed information of TA system TA212061

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2027435..2027742
• Replicon: chromosome
• Accession: NZ_CP080551
• Organism: Staphylococcus aureus strain HL18840

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: JMO13_RS09955
• Protein ID: WP_011447039.1
• Coordinates: 2027566..2027742 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2027435..2027574 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO13_RS09915 (2022786)	2022786..2023046	+	261	WP_001791826.1	hypothetical protein	-
JMO13_RS09920 (2023099)	2023099..2023439	-	341	Protein_1930	complement inhibitor SCIN-A	-
JMO13_RS09925 (2024123)	2024123..2024571	+	449	Protein_1931	chemotaxis-inhibiting protein CHIPS	-
JMO13_RS09930 (2024666)	2024666..2025001	-	336	Protein_1932	SH3 domain-containing protein	-
JMO13_RS09935 (2025651)	2025651..2026142	-	492	WP_000919350.1	staphylokinase	-
JMO13_RS09940 (2026333)	2026333..2027088	-	756	WP_000861038.1	CHAP domain-containing protein	-
JMO13_RS09945 (2027100)	2027100..2027354	-	255	WP_000611512.1	phage holin	-
JMO13_RS09950 (2027406)	2027406..2027513	+	108	WP_001791821.1	hypothetical protein	-
- (2027435)	2027435..2027574	+	140	NuclAT_0	-	Antitoxin
- (2027435)	2027435..2027574	+	140	NuclAT_0	-	Antitoxin
- (2027435)	2027435..2027574	+	140	NuclAT_0	-	Antitoxin
- (2027435)	2027435..2027574	+	140	NuclAT_0	-	Antitoxin
JMO13_RS09955 (2027566)	2027566..2027742	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
JMO13_RS09960 (2027892)	2027892..2028188	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
JMO13_RS09965 (2028246)	2028246..2028533	-	288	WP_001040261.1	hypothetical protein	-
JMO13_RS09970 (2028580)	2028580..2028732	-	153	WP_001153681.1	hypothetical protein	-
JMO13_RS09975 (2028722)	2028722..2032507	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / scn / chp / sak / hlb / groEL	2023099..2075308	52209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T212061 WP_011447039.1 NZ_CP080551:c2027742-2027566 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T212061 NZ_CP106924:4211100-4212017 [Escherichia coli]
ATGGATAAAACCTCCCCCTACTACCGCCAGGTCGCTCTGTTGGTGCGAGCATTACCCTGGGTCGCTAACGAGTCCTGTTT
TGCGCTGAAAGGCGGAACGGCGATCAACTTATTCATCCATGATTTTCCCCGATTGTCCGTTGATATCGATCTGGCCTGGA
TACCGCTGGAAAGCAGAGAGGTCGCGCTGCCCAACGTGCGGGAGGCGCTCACCCGTATCGCCGCAGAACTGAAAGCGCAA
ACCGGGATCCGTGCAGTGCTGCAAACCCATAATCCCGATGAGATGCGCATCATTGTCACCACTGACGATGCGCAAATTAA
AATTGAAGTCTCGCCAGTTGCCCGGGGGACACTATATCCTCCGCAAGAACGCGATATCGTCGGAGCCGTGGAGGAAGAAT
TTGGCTTTGCCGCGCTCCCGGTGGTCTCACTGCCCGATTTATACGGTGGCAAGCTATGTGCTGCGTTAGATCGCCAGCAC
CCCAGAGATTTTTACGACGTCAAAATGCTCCTTGATACACAAGGAATTGATCGCTCGATATTCAATGGTTTTATCGTGTA
CTTGCTCAGCCATAACCGCCCATTATCCGAAGTGCTTAACCCACGTTGGAAGGATATTACTGAACCCTTTCAAAATGAAT
TCAGCGGTATGACTTTTGAGGAAGTATCACTGGAAGAGCTAAAAGAGGTCCCGGAAAGAATGCTCAGCACGTTGAAAACG
CATTTCACTCAACAGGATTTCGACTTCCTGATGTCATTTAAACGCGGCGAGCCAGACTGGAATTTAGCGCCAGAGCCCCA
CATTCAGAATTTGCCAGCCGTTCAATGGAAGCTGCGCAATATTGGACAGATGTCGGAGGAAAAGCGCGCGCAGTCACTGG
AGAAACTAGAAAAGGTCATGACAGAATGGCTACGTTAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT212061 NZ_CP080551:2027435-2027574 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin