Detailed information of TA system TA212058

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1863451..1863631
• Replicon: chromosome
• Accession: NZ_CP080551
• Organism: Staphylococcus aureus strain HL18840

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JMO13_RS08935
• Protein ID: WP_001801861.1
• Coordinates: 1863451..1863546 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1863574..1863631 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO13_RS08900	1858492..1859118	+	627	WP_000669021.1	hypothetical protein	-
JMO13_RS08905	1859159..1859500	+	342	WP_000627547.1	DUF3969 family protein	-
JMO13_RS08910	1859601..1860173	+	573	WP_000414206.1	hypothetical protein	-
JMO13_RS08915	1860371..1860999	-	629	Protein_1765	ImmA/IrrE family metallo-endopeptidase	-
JMO13_RS08920	1861299..1861475	-	177	WP_000375476.1	hypothetical protein	-
JMO13_RS08925	1861486..1861869	-	384	WP_000070811.1	hypothetical protein	-
JMO13_RS08930	1862554..1863000	-	447	WP_000747802.1	DUF1433 domain-containing protein	-
JMO13_RS08935	1863451..1863546	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1863574..1863631	-	58	-	-	Antitoxin
JMO13_RS08940	1863669..1863770	+	102	WP_001791232.1	hypothetical protein	-
JMO13_RS08945	1863748..1863930	-	183	Protein_1771	transposase	-
JMO13_RS08950	1864118..1864492	-	375	WP_000695818.1	DUF1433 domain-containing protein	-
JMO13_RS08955	1864514..1864792	-	279	WP_001798632.1	DUF1433 domain-containing protein	-
JMO13_RS08960	1865098..1865514	-	417	WP_020978241.1	DUF1433 domain-containing protein	-
JMO13_RS08965	1866161..1867279	-	1119	WP_000072558.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1855934..1890782	34848

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T212058 WP_001801861.1 NZ_CP080551:1863451-1863546 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T212058 NZ_CP106924:3591809-3592351 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT212058 NZ_CP080551:c1863631-1863574 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin