Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 865570..865984 Replicon chromosome
Accession NZ_CP080551
Organism Staphylococcus aureus strain HL18840

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMO13_RS04195 Protein ID WP_061477612.1
Coordinates 865570..865821 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMO13_RS04200 Protein ID WP_000028424.1
Coordinates 865811..865984 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO13_RS04145 (860909) 860909..861580 + 672 WP_016028251.1 putative HNHc nuclease -
JMO13_RS04150 (861690) 861690..862349 - 660 WP_016028252.1 hypothetical protein -
JMO13_RS04155 (862395) 862395..863165 + 771 WP_000190226.1 conserved phage C-terminal domain-containing protein -
JMO13_RS04160 (863175) 863175..863948 + 774 WP_000803028.1 ATP-binding protein -
JMO13_RS04165 (863942) 863942..864100 + 159 WP_000256589.1 hypothetical protein -
JMO13_RS04170 (864114) 864114..864335 + 222 WP_001123681.1 DUF3269 family protein -
JMO13_RS04175 (864346) 864346..864750 + 405 WP_000049798.1 DUF1064 domain-containing protein -
JMO13_RS04180 (864755) 864755..864940 + 186 WP_016028253.1 DUF3113 family protein -
JMO13_RS04185 (864941) 864941..865309 + 369 WP_016028254.1 SA1788 family PVL leukocidin-associated protein -
JMO13_RS04190 (865313) 865313..865555 + 243 WP_000131389.1 SAV1978 family virulence-associated passenger protein -
JMO13_RS04195 (865570) 865570..865821 + 252 WP_061477612.1 DUF1024 family protein Toxin
JMO13_RS04200 (865811) 865811..865984 + 174 WP_000028424.1 hypothetical protein Antitoxin
JMO13_RS04205 (865985) 865985..866266 + 282 WP_000454994.1 hypothetical protein -
JMO13_RS04210 (866267) 866267..866428 + 162 WP_000889683.1 hypothetical protein -
JMO13_RS04215 (866443) 866443..866976 + 534 WP_220359219.1 dUTP diphosphatase -
JMO13_RS04220 (867013) 867013..867219 + 207 WP_016028256.1 DUF1381 domain-containing protein -
JMO13_RS04225 (867216) 867216..867389 + 174 WP_000595257.1 transcriptional activator RinB -
JMO13_RS04230 (867390) 867390..867752 + 363 WP_000383791.1 hypothetical protein -
JMO13_RS04235 (867753) 867753..867899 + 147 WP_000989961.1 hypothetical protein -
JMO13_RS04240 (867914) 867914..868333 + 420 WP_000058634.1 transcriptional regulator -
JMO13_RS04245 (868520) 868520..868960 + 441 WP_009560332.1 terminase small subunit -
JMO13_RS04250 (868947) 868947..870224 + 1278 WP_009560330.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 851373..895633 44260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9361.22 Da        Isoelectric Point: 3.8464

>T212057 WP_061477612.1 NZ_CP080551:865570-865821 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T212057 NZ_CP106924:3557835-3558053 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT212057 WP_000028424.1 NZ_CP080551:865811-865984 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT212057 NZ_CP106924:3557435-3557809 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References