Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2561200..2561717 Replicon chromosome
Accession NZ_CP080550
Organism Staphylococcus aureus strain HL18883

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag JMO14_RS12895 Protein ID WP_000113265.1
Coordinates 2561200..2561466 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag JMO14_RS12900 Protein ID WP_000584499.1
Coordinates 2561466..2561717 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO14_RS12865 (JMO14_002575) 2556628..2557164 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
JMO14_RS12870 (JMO14_002576) 2557398..2558222 - 825 WP_000572038.1 formate/nitrite transporter family protein -
JMO14_RS12875 (JMO14_002577) 2558439..2558621 - 183 WP_000230292.1 hypothetical protein -
JMO14_RS12880 (JMO14_002578) 2558705..2559172 - 468 WP_000153347.1 SRPBCC domain-containing protein -
JMO14_RS12885 (JMO14_002579) 2559358..2560905 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JMO14_RS12890 (JMO14_002580) 2561094..2561165 - 72 Protein_2513 hypothetical protein -
JMO14_RS12895 (JMO14_002581) 2561200..2561466 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
JMO14_RS12900 (JMO14_002582) 2561466..2561717 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMO14_RS12905 (JMO14_002583) 2561882..2561962 - 81 WP_223197974.1 hypothetical protein -
JMO14_RS12910 (JMO14_002584) 2561990..2562589 - 600 WP_000162810.1 DsbA family protein -
JMO14_RS12915 (JMO14_002585) 2562608..2562970 - 363 WP_000819843.1 DUF4467 domain-containing protein -
JMO14_RS12920 (JMO14_002586) 2563225..2564475 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
JMO14_RS12925 (JMO14_002587) 2564572..2565303 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
JMO14_RS12930 (JMO14_002588) 2565300..2566019 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T212052 WP_000113265.1 NZ_CP080550:c2561466-2561200 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T212052 NZ_CP106924:1985054-1985157 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT212052 WP_000584499.1 NZ_CP080550:c2561717-2561466 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT212052 NZ_CP106924:c1985195-1984924 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAAATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References