Detailed information of TA system TA212046

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2002943..2003123
• Replicon: chromosome
• Accession: NZ_CP080550
• Organism: Staphylococcus aureus strain HL18883

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JMO14_RS09840
• Protein ID: WP_001801861.1
• Coordinates: 2002943..2003038 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2003066..2003123 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO14_RS09810 (JMO14_001963)	1998106..1998756	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
JMO14_RS09815 (JMO14_001964)	1998837..1999832	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
JMO14_RS09820 (JMO14_001965)	1999907..2000533	+	627	WP_000669024.1	hypothetical protein	-
JMO14_RS09825 (JMO14_001966)	2000574..2000915	+	342	WP_000627540.1	DUF3969 family protein	-
JMO14_RS09830 (JMO14_001967)	2001016..2001588	+	573	WP_000414216.1	hypothetical protein	-
JMO14_RS09835 (JMO14_001968)	2001786..2002798	-	1013	Protein_1950	IS3 family transposase	-
JMO14_RS09840 (JMO14_001969)	2002943..2003038	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2003066..2003123	-	58	-	-	Antitoxin
JMO14_RS09845 (JMO14_001970)	2003161..2003262	+	102	WP_001792025.1	hypothetical protein	-
JMO14_RS09850 (JMO14_001971)	2003240..2003401	-	162	Protein_1953	transposase	-
JMO14_RS09855 (JMO14_001972)	2003386..2003796	-	411	WP_001808705.1	IS21 family transposase	-
JMO14_RS09860 (JMO14_001973)	2004338..2005568	-	1231	Protein_1955	restriction endonuclease subunit S	-
JMO14_RS09865 (JMO14_001974)	2005561..2007117	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
JMO14_RS09870 (JMO14_001975)	2007281..2007415	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1978925..2077670	98745

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T212046 WP_001801861.1 NZ_CP080550:2002943-2003038 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T212046 NZ_CP106924:1007690-1008025 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT212046 NZ_CP080550:c2003123-2003066 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin