Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1668568..1669147 | Replicon | chromosome |
| Accession | NZ_CP080550 | ||
| Organism | Staphylococcus aureus strain HL18883 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | JMO14_RS08180 | Protein ID | WP_001025401.1 |
| Coordinates | 1668902..1669147 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1668568..1668933 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO14_RS08140 (JMO14_001629) | 1665312..1665869 | - | 558 | WP_000645045.1 | DUF2815 family protein | - |
| JMO14_RS08145 (JMO14_001630) | 1665895..1667061 | - | 1167 | WP_000762525.1 | DUF2800 domain-containing protein | - |
| JMO14_RS08150 (JMO14_001631) | 1667058..1667420 | - | 363 | WP_000279445.1 | hypothetical protein | - |
| JMO14_RS08155 (JMO14_001632) | 1667435..1667758 | - | 324 | WP_000174995.1 | hypothetical protein | - |
| JMO14_RS08160 (JMO14_001633) | 1667837..1667998 | - | 162 | WP_015986189.1 | DUF1270 family protein | - |
| JMO14_RS08165 (JMO14_001634) | 1668010..1668273 | - | 264 | WP_044426023.1 | helix-turn-helix domain-containing protein | - |
| JMO14_RS08170 (JMO14_001635) | 1668298..1668513 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| JMO14_RS08175 (JMO14_001636) | 1668568..1668933 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| JMO14_RS08180 (JMO14_001637) | 1668902..1669147 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| JMO14_RS08185 (JMO14_001638) | 1669203..1669412 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| JMO14_RS08190 (JMO14_001639) | 1669402..1669545 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| JMO14_RS08195 (JMO14_001640) | 1669560..1670003 | - | 444 | WP_044414793.1 | hypothetical protein | - |
| JMO14_RS08200 (JMO14_001641) | 1670027..1670248 | - | 222 | WP_031887876.1 | DUF739 family protein | - |
| JMO14_RS08205 (JMO14_001642) | 1670409..1671179 | + | 771 | WP_031887877.1 | S24 family peptidase | - |
| JMO14_RS08210 (JMO14_001643) | 1671191..1671337 | + | 147 | WP_001049401.1 | hypothetical protein | - |
| JMO14_RS08215 (JMO14_001644) | 1671334..1671519 | + | 186 | WP_000109189.1 | hypothetical protein | - |
| JMO14_RS08220 (JMO14_001645) | 1671589..1671756 | + | 168 | WP_000705241.1 | hypothetical protein | - |
| JMO14_RS08225 (JMO14_001646) | 1671896..1672600 | + | 705 | WP_000440838.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| JMO14_RS08230 (JMO14_001647) | 1672811..1674016 | + | 1206 | WP_031766111.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | ebp / gnd | 1578959..1698378 | 119419 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T212043 WP_001025401.1 NZ_CP080550:c1669147-1668902 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T212043 NZ_CP106924:305172-305699 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGAATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGAATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
Antitoxin
Download Length: 366 bp
>AT212043 NZ_CP080550:1668568-1668933 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
