Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2577453..2577637 Replicon chromosome
Accession NZ_CP080548
Organism Staphylococcus aureus strain HL18888

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag JMO15_RS12955 Protein ID WP_000482652.1
Coordinates 2577530..2577637 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2577453..2577513 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO15_RS12940 2572908..2573039 - 132 WP_223197975.1 hypothetical protein -
JMO15_RS12945 2573306..2575039 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
JMO15_RS12950 2575064..2576827 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2577453..2577513 + 61 - - Antitoxin
JMO15_RS12955 2577530..2577637 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
JMO15_RS12960 2577771..2578157 - 387 WP_000779360.1 flippase GtxA -
JMO15_RS12965 2578425..2579567 + 1143 WP_001176863.1 glycerate kinase -
JMO15_RS12970 2579627..2580286 + 660 WP_000831298.1 membrane protein -
JMO15_RS12975 2580468..2581679 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
JMO15_RS12980 2581802..2582275 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T212039 WP_000482652.1 NZ_CP080548:c2577637-2577530 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T212039 NZ_CP106920:2709-2987 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 61 bp

>AT212039 NZ_CP080548:2577453-2577513 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References