Detailed information of TA system TA212039

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2577453..2577637
• Replicon: chromosome
• Accession: NZ_CP080548
• Organism: Staphylococcus aureus strain HL18888

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: JMO15_RS12955
• Protein ID: WP_000482652.1
• Coordinates: 2577530..2577637 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2577453..2577513 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO15_RS12940	2572908..2573039	-	132	WP_223197975.1	hypothetical protein	-
JMO15_RS12945	2573306..2575039	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
JMO15_RS12950	2575064..2576827	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2577453..2577513	+	61	-	-	Antitoxin
JMO15_RS12955	2577530..2577637	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
JMO15_RS12960	2577771..2578157	-	387	WP_000779360.1	flippase GtxA	-
JMO15_RS12965	2578425..2579567	+	1143	WP_001176863.1	glycerate kinase	-
JMO15_RS12970	2579627..2580286	+	660	WP_000831298.1	membrane protein	-
JMO15_RS12975	2580468..2581679	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JMO15_RS12980	2581802..2582275	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T212039 WP_000482652.1 NZ_CP080548:c2577637-2577530 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T212039 NZ_CP106920:2709-2987 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT212039 NZ_CP080548:2577453-2577513 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin