Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2289981..2290197 Replicon chromosome
Accession NZ_CP080548
Organism Staphylococcus aureus strain HL18888

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag JMO15_RS11460 Protein ID WP_001802298.1
Coordinates 2290093..2290197 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2289981..2290036 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO15_RS11440 2286187..2286852 - 666 WP_001024095.1 SDR family oxidoreductase -
JMO15_RS11445 2287004..2287324 + 321 WP_000003760.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
JMO15_RS11450 2287326..2288303 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
JMO15_RS11455 2288569..2289660 + 1092 WP_000495669.1 hypothetical protein -
- 2289981..2290036 + 56 - - Antitoxin
JMO15_RS11460 2290093..2290197 - 105 WP_001802298.1 hypothetical protein Toxin
JMO15_RS11465 2290877..2291035 + 159 WP_001792784.1 hypothetical protein -
JMO15_RS11470 2291693..2292550 - 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
JMO15_RS11475 2292618..2293400 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T212036 WP_001802298.1 NZ_CP080548:c2290197-2290093 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T212036 NZ_CP106918:1180864-1181046 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGTCATTCGCAATA
TAAGCACCCAACAAAAAAGTACCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 56 bp

>AT212036 NZ_CP080548:2289981-2290036 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References