Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1644954..1645368 | Replicon | chromosome |
| Accession | NZ_CP080548 | ||
| Organism | Staphylococcus aureus strain HL18888 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | JMO15_RS07940 | Protein ID | WP_031267622.1 |
| Coordinates | 1645117..1645368 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JMO15_RS07935 | Protein ID | WP_000028424.1 |
| Coordinates | 1644954..1645127 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO15_RS07895 (1640218) | 1640218..1640508 | - | 291 | WP_000665205.1 | VRR-NUC domain-containing protein | - |
| JMO15_RS07900 (1640642) | 1640642..1640740 | + | 99 | WP_001801650.1 | hypothetical protein | - |
| JMO15_RS07905 (1640849) | 1640849..1643296 | - | 2448 | WP_000884870.1 | VapE family protein | - |
| JMO15_RS07910 (1643584) | 1643584..1643784 | - | 201 | WP_000265252.1 | DUF1514 family protein | - |
| JMO15_RS07915 (1643852) | 1643852..1644004 | - | 153 | WP_000595263.1 | transcriptional activator RinB | - |
| JMO15_RS07920 (1644001) | 1644001..1644207 | - | 207 | WP_000195810.1 | DUF1381 domain-containing protein | - |
| JMO15_RS07925 (1644244) | 1644244..1644777 | - | 534 | WP_063653166.1 | dUTPase | - |
| JMO15_RS07930 (1644792) | 1644792..1644953 | - | 162 | WP_000889684.1 | hypothetical protein | - |
| JMO15_RS07935 (1644954) | 1644954..1645127 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| JMO15_RS07940 (1645117) | 1645117..1645368 | - | 252 | WP_031267622.1 | DUF1024 family protein | Toxin |
| JMO15_RS07945 (1645361) | 1645361..1645668 | - | 308 | Protein_1571 | hypothetical protein | - |
| JMO15_RS07950 (1645665) | 1645665..1646012 | - | 348 | WP_000979209.1 | YopX family protein | - |
| JMO15_RS07955 (1646009) | 1646009..1646389 | - | 381 | WP_001668982.1 | hypothetical protein | - |
| JMO15_RS07960 (1646392) | 1646392..1646598 | - | 207 | WP_000693989.1 | hypothetical protein | - |
| JMO15_RS07965 (1646612) | 1646612..1646860 | - | 249 | WP_060474161.1 | SAV1978 family virulence-associated passenger protein | - |
| JMO15_RS07970 (1646860) | 1646860..1647114 | - | 255 | WP_000022722.1 | DUF3310 domain-containing protein | - |
| JMO15_RS07975 (1647111) | 1647111..1647515 | - | 405 | WP_044426014.1 | SA1788 family PVL leukocidin-associated protein | - |
| JMO15_RS07980 (1647515) | 1647515..1647700 | - | 186 | WP_001164629.1 | DUF3113 family protein | - |
| JMO15_RS07985 (1647713) | 1647713..1649665 | - | 1953 | WP_078064460.1 | DNA polymerase | - |
| JMO15_RS07990 (1649733) | 1649733..1650290 | - | 558 | WP_000645045.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1613298..1671381 | 58083 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9419.35 Da Isoelectric Point: 3.9476
>T212026 WP_031267622.1 NZ_CP080548:c1645368-1645117 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T212026 NZ_CP106912:c4917279-4916995 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT212026 WP_000028424.1 NZ_CP080548:c1645127-1644954 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT212026 NZ_CP106912:c4917511-4917269 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|