Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 926648..927236 Replicon chromosome
Accession NZ_CP080536
Organism Acidithiobacillus ferriphilus strain GT2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K1Y48_RS04580 Protein ID WP_229066265.1
Coordinates 926648..926929 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K1Y48_RS04585 Protein ID WP_215849504.1
Coordinates 926940..927236 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1Y48_RS04560 (K1Y48_04580) 923404..924480 + 1077 WP_215849673.1 DUF4263 domain-containing protein -
K1Y48_RS04565 (K1Y48_04585) 924552..925166 + 615 WP_215849507.1 hypothetical protein -
K1Y48_RS04570 (K1Y48_04590) 925276..925653 + 378 WP_229066264.1 DUF2513 domain-containing protein -
K1Y48_RS04575 (K1Y48_04595) 925728..926444 + 717 WP_215849505.1 hypothetical protein -
K1Y48_RS04580 (K1Y48_04600) 926648..926929 + 282 WP_229066265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1Y48_RS04585 (K1Y48_04605) 926940..927236 + 297 WP_215849504.1 HigA family addiction module antitoxin Antitoxin
K1Y48_RS04590 (K1Y48_04610) 927934..928188 - 255 WP_215849503.1 Txe/YoeB family addiction module toxin -
K1Y48_RS04595 (K1Y48_04615) 928185..928436 - 252 WP_035191769.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
K1Y48_RS04600 (K1Y48_04620) 928803..930314 + 1512 WP_215849502.1 PQQ-binding-like beta-propeller repeat protein -
K1Y48_RS04605 (K1Y48_04625) 930431..931264 + 834 WP_229066266.1 ferritin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 923404..927303 3899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10740.16 Da        Isoelectric Point: 7.3598

>T212018 WP_229066265.1 NZ_CP080536:926648-926929 [Acidithiobacillus ferriphilus]
MIQTFANTETEGFFVTGKSRRLPSEILKRAAMRLNQLHAATELNDLHLPPSNHLEALSGNRIGQWSIRINQQWRVCFKFE
NGDAFNVEIVDYH

Download         Length: 282 bp

>T212018 NZ_CP106912:329340-329708 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11001.80 Da        Isoelectric Point: 8.5298

>AT212018 WP_215849504.1 NZ_CP080536:926940-927236 [Acidithiobacillus ferriphilus]
MIYNGLTPIHPGEYLAELLEELHISQALFARTIGVSPMRISHIVKGKRPVTAELALLFAKAFEQTPQYWLNLQASYDLKT
AEKSIANRLFSIHSLAHA

Download         Length: 297 bp

>AT212018 NZ_CP106912:329122-329343 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References