Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 7284890..7285566 Replicon chromosome
Accession NZ_CP080521
Organism Pseudonocardia sp. DSM 110487

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag K1T35_RS34040 Protein ID WP_220255858.1
Coordinates 7284890..7285252 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K1T35_RS34045 Protein ID WP_220255859.1
Coordinates 7285249..7285566 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T35_RS34015 (K1T35_34015) 7279960..7280826 + 867 WP_220255855.1 aldo/keto reductase family oxidoreductase -
K1T35_RS34020 (K1T35_34020) 7281062..7281832 - 771 WP_220255856.1 SDR family oxidoreductase -
K1T35_RS34025 (K1T35_34025) 7281832..7283148 - 1317 WP_220255857.1 M20/M25/M40 family metallo-hydrolase -
K1T35_RS34035 (K1T35_34035) 7283369..7284613 - 1245 WP_255622704.1 recombinase family protein -
K1T35_RS34040 (K1T35_34040) 7284890..7285252 + 363 WP_220255858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T35_RS34045 (K1T35_34045) 7285249..7285566 + 318 WP_220255859.1 helix-turn-helix transcriptional regulator Antitoxin
K1T35_RS34050 (K1T35_34050) 7285735..7286493 - 759 WP_220255860.1 hypothetical protein -
K1T35_RS34055 (K1T35_34055) 7286983..7287789 - 807 WP_220255861.1 alpha/beta hydrolase -
K1T35_RS34060 (K1T35_34060) 7287956..7288531 + 576 WP_220255862.1 PadR family transcriptional regulator -
K1T35_RS34065 (K1T35_34065) 7288534..7288944 + 411 WP_255621036.1 alcohol dehydrogenase catalytic domain-containing protein -
K1T35_RS34070 (K1T35_34070) 7289292..7289963 + 672 WP_220255863.1 site-specific integrase -
K1T35_RS34075 (K1T35_34075) 7289964..7290176 - 213 WP_220255864.1 hypothetical protein -
K1T35_RS34080 (K1T35_34080) 7290348..7290566 - 219 WP_220255865.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13786.54 Da        Isoelectric Point: 5.2060

>T211986 WP_220255858.1 NZ_CP080521:7284890-7285252 [Pseudonocardia sp. DSM 110487]
VAPGQWQVYVVNEVRDWIDSLDATTHTRVVQAIDTLADVGPGLGRPLVDTIHGSSIANLKELRPGTVRILFAFDPWRDSI
LLVAGDKAGRWTQWYREAIPLAEQRYERYLKERTQEEEQR

Download         Length: 363 bp

>T211986 NZ_CP106892:c85185-84880 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11360.85 Da        Isoelectric Point: 9.8252

>AT211986 WP_220255859.1 NZ_CP080521:7285249-7285566 [Pseudonocardia sp. DSM 110487]
MTSHVAWNDIRAEHIARAGGEAAVEAGKRELLAEVVGHRLAEIRRARGLTQQQVADRMGVSKGRVSQIERGKISGQDVLA
RYATALGGRLHQAIYFDDGDITAIA

Download         Length: 318 bp

>AT211986 NZ_CP106892:c85403-85185 [Klebsiella pneumoniae]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References