Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1384158..1384767 Replicon chromosome
Accession NZ_CP080507
Organism Horticoccus luteus strain KSB-15

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K0B96_RS05660 Protein ID WP_220164813.1
Coordinates 1384489..1384767 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K0B96_RS05655 Protein ID WP_220164811.1
Coordinates 1384158..1384457 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0B96_RS05630 (K0B96_05630) 1379785..1380198 + 414 WP_220164792.1 DUF1398 family protein -
K0B96_RS05635 (K0B96_05635) 1380224..1381090 + 867 WP_220164794.1 RNA polymerase sigma factor -
K0B96_RS05640 (K0B96_05640) 1381193..1381654 - 462 WP_220164797.1 DUF5069 domain-containing protein -
K0B96_RS05645 (K0B96_05645) 1381885..1382673 + 789 WP_220164799.1 PEP-CTERM sorting domain-containing protein -
K0B96_RS05650 (K0B96_05650) 1382678..1383892 + 1215 WP_220164809.1 glycosyltransferase -
K0B96_RS05655 (K0B96_05655) 1384158..1384457 - 300 WP_220164811.1 HigA family addiction module antitoxin Antitoxin
K0B96_RS05660 (K0B96_05660) 1384489..1384767 - 279 WP_220164813.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0B96_RS05665 (K0B96_05665) 1384826..1387072 - 2247 WP_220164815.1 NADP-dependent isocitrate dehydrogenase -
K0B96_RS05670 (K0B96_05670) 1387399..1388919 + 1521 WP_220164817.1 xylulokinase -
K0B96_RS05675 (K0B96_05675) 1389066..1389677 - 612 WP_220164820.1 YdeI/OmpD-associated family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10755.30 Da        Isoelectric Point: 10.5712

>T211954 WP_220164813.1 NZ_CP080507:c1384767-1384489 [Horticoccus luteus]
MIQSFADHDTEQLFREEKNRRFSAIARVALRKLFQMNRAGVLQDLAVPPRNRLEALKGDRAGLHAIRINDQWRLVFRWTE
NGPAEVAIVDYH

Download         Length: 279 bp

>T211954 NZ_CP106885:1457784-1458092 [Achromobacter spanius]
ATGAGCAAATTACGCGACTTCGACGCAGCGAATTATTTGAAAGATGACGAAACGATCGCGCATTACCTGGCCGACGCGGC
AGCGGAGGACGATCCTGATGCGTTCCTGCAAGCCCTAGGCGACGTGGCGCGCGCGCGCGGCATCACAGAAATCGCTCGTG
AAACAGGGCTTGCCAGAACGAATCTTTATCGGGTGCTCGCGCCCGGCGCGAACCCCAGCTATCACACCCTGCGCAAGGTC
ATGAACGCGCTTGGTGTATCGCTCACCGCCCTTGTCAGGCGCAAATCCGATCCCACGCCGCAAGGCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10855.71 Da        Isoelectric Point: 10.3582

>AT211954 WP_220164811.1 NZ_CP080507:c1384457-1384158 [Horticoccus luteus]
MNPPITPGEILLEEYLTPMGISQNAMARAIGVSPRAINEIVLGHRSITPVMSIRFGAFFGQTPEFWHGLQVECDFRALGK
KQKKLTAKIRPAQSLGHAA

Download         Length: 300 bp

>AT211954 NZ_CP106885:1457578-1457787 [Achromobacter spanius]
ATGCATGGGAATTTCGGCGACGTAGAGGCGGTGGGTGAGGGCGTCAGTGAAATGCGCGTGAGTATTGGCGCCGGCTACCG
CCTGTATTACGCCCGGGCCGACGAGCTGGTCTACGTGCTGCTTTGTGGCGGTGACAAGACCAGCCAGGCCAGGGATATCG
CCCGCGCCAAACGCCTTTGGACGGACATTAAGCGGAGCATCGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References