21195

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 742780..744128 Replicon chromosome
Accession NC_007146
Organism Haemophilus influenzae 86-028NP

Toxin (Protein)


Gene name HipT Uniprot ID Q4QMQ2
Locus tag NTHI_RS03785 Protein ID WP_011272157.1
Coordinates 742780..743811 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q4QMQ1
Locus tag NTHI_RS03790 Protein ID WP_011272158.1
Coordinates 743808..744128 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI_RS03775 (NTHI0783) 739300..741045 + 1746 WP_011272155.1 ABC transporter ATP-binding protein/permease -
NTHI_RS03780 (NTHI0785) 741038..742696 + 1659 WP_011272156.1 thiol reductant ABC exporter subunit CydC -
NTHI_RS03785 (NTHI0786) 742780..743811 - 1032 WP_011272157.1 type II toxin-antitoxin system HipA family toxin Toxin
NTHI_RS03790 (NTHI0787) 743808..744128 - 321 WP_011272158.1 type II toxin-antitoxin system HipA family toxin Antitoxin
NTHI_RS03795 (NTHI0788) 744116..744424 - 309 WP_011272159.1 helix-turn-helix domain-containing protein -
NTHI_RS03800 (NTHI0789) 744629..745630 - 1002 WP_011272160.1 class II fructose-bisphosphatase -
NTHI_RS03805 (NTHI0790) 745792..746010 + 219 WP_005650820.1 cell division protein ZapB -
NTHI_RS03810 (NTHI0791) 746109..746549 + 441 WP_005667635.1 FMN-binding protein MioC -
NTHI_RS03815 (NTHI0792) 746546..746980 + 435 WP_005650818.1 D-tyrosyl-tRNA(Tyr) deacylase -
NTHI_RS03820 (NTHI0793) 747287..747763 - 477 WP_006995249.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
NTHI_RS03825 (NTHI0794) 747760..748437 - 678 WP_011272161.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
NTHI_RS03830 (NTHI0795) 748437..748715 - 279 WP_005661211.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39845.35 Da        Isoelectric Point: 6.3721

>T21195 WP_011272157.1 NC_007146:c743811-742780 [Haemophilus influenzae 86-028NP]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDDHFDSVDQQ
GHYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNQKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

>T21195 NC_007146:c743811-742780 [Haemophilus influenzae 86-028NP]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAAAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTACACTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTGCCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGGATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGATCACTTTGACAGCGTAGATCAACAG
GGACATTACATTTTAAAGCCTTCGCCCGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCAGAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCATTACTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12437.12 Da        Isoelectric Point: 5.9670

>AT21195 WP_011272158.1 NC_007146:c744128-743808 [Haemophilus influenzae 86-028NP]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT21195 NC_007146:c744128-743808 [Haemophilus influenzae 86-028NP]
ATGCGCGATTTAGTCCGCTCGGGCAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGAGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCCCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QMQ2

Antitoxin

Source ID Structure
AlphaFold DB Q4QMQ1

References