Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1217981..1218491 Replicon chromosome
Accession NZ_CP080458
Organism Staphylococcus carnosus strain KCTC 3580

Toxin (Protein)


Gene name yoeB Uniprot ID B9DKQ4
Locus tag Sta3580_RS05805 Protein ID WP_012664284.1
Coordinates 1218222..1218491 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B9DKQ3
Locus tag Sta3580_RS05800 Protein ID WP_012664283.1
Coordinates 1217981..1218229 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sta3580_RS05780 (Sta3580_05735) 1214166..1214678 + 513 WP_012664280.1 YwhD family protein -
Sta3580_RS05785 (Sta3580_05745) 1214862..1215479 - 618 WP_012664281.1 LysE family transporter -
Sta3580_RS05790 1215686..1215925 - 240 WP_231635373.1 fatty acid desaturase -
Sta3580_RS05795 (Sta3580_05755) 1216229..1217641 + 1413 WP_012664282.1 PLP-dependent aminotransferase family protein -
Sta3580_RS05800 (Sta3580_05760) 1217981..1218229 + 249 WP_012664283.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Sta3580_RS05805 (Sta3580_05765) 1218222..1218491 + 270 WP_012664284.1 Txe/YoeB family addiction module toxin Toxin
Sta3580_RS05810 (Sta3580_05770) 1218978..1220168 + 1191 WP_012664285.1 amidohydrolase -
Sta3580_RS05815 (Sta3580_05775) 1220329..1220745 + 417 WP_012664286.1 DUF1934 family protein -
Sta3580_RS05820 (Sta3580_05780) 1220747..1222411 + 1665 WP_012664287.1 arginine--tRNA ligase -
Sta3580_RS05825 (Sta3580_05785) 1222543..1223445 + 903 WP_012664288.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10459.95 Da        Isoelectric Point: 10.0493

>T211885 WP_012664284.1 NZ_CP080458:1218222-1218491 [Staphylococcus carnosus]
MSKLNISFSPEAFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESIL
AASCKYHYQ

Download         Length: 270 bp

>T211885 NZ_CP106821:c1656788-1656606 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9305.30 Da        Isoelectric Point: 4.2081

>AT211885 WP_012664283.1 NZ_CP080458:1217981-1218229 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Download         Length: 249 bp

>AT211885 NZ_CP106821:c1656504-1656103 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9DKQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A380F8S2

References