Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1769394..1769964 Replicon chromosome
Accession NZ_CP080380
Organism Microbacterium sp. PAMC22086

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KY497_RS08900 Protein ID WP_218682949.1
Coordinates 1769394..1769675 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KY497_RS08905 Protein ID WP_044496365.1
Coordinates 1769662..1769964 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY497_RS08870 (KY497_08870) 1764526..1765836 - 1311 WP_219868878.1 DNA recombination protein RmuC -
KY497_RS08875 (KY497_08875) 1765920..1766522 - 603 WP_219868879.1 3'-5' exonuclease -
KY497_RS08880 (KY497_08880) 1766582..1767322 + 741 WP_219868880.1 class I SAM-dependent methyltransferase -
KY497_RS08885 (KY497_08885) 1767375..1768448 + 1074 WP_218682665.1 redox-regulated ATPase YchF -
KY497_RS08890 (KY497_08890) 1768496..1768708 - 213 WP_218682952.1 helix-turn-helix transcriptional regulator -
KY497_RS08895 (KY497_08895) 1768711..1769184 - 474 WP_218682950.1 hypothetical protein -
KY497_RS08900 (KY497_08900) 1769394..1769675 + 282 WP_218682949.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KY497_RS08905 (KY497_08905) 1769662..1769964 + 303 WP_044496365.1 HigA family addiction module antitoxin Antitoxin
KY497_RS08910 (KY497_08910) 1770039..1770785 + 747 WP_258185967.1 alpha/beta hydrolase -
KY497_RS08915 (KY497_08915) 1770910..1771218 + 309 WP_219868882.1 transposase -
KY497_RS08920 (KY497_08920) 1771215..1771688 + 474 WP_219868883.1 hypothetical protein -
KY497_RS08925 (KY497_08925) 1771873..1772448 + 576 WP_219868884.1 alpha/beta hydrolase -
KY497_RS08930 (KY497_08930) 1772465..1772809 - 345 WP_017828685.1 LysR family transcriptional regulator -
KY497_RS08935 (KY497_08935) 1772917..1773216 - 300 WP_017828684.1 hypothetical protein -
KY497_RS08940 (KY497_08940) 1773324..1773833 - 510 WP_229778915.1 GNAT family N-acetyltransferase -
KY497_RS08945 (KY497_08945) 1773925..1774467 + 543 WP_141386683.1 DNA starvation/stationary phase protection protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10982.46 Da        Isoelectric Point: 10.1892

>T211835 WP_218682949.1 NZ_CP080380:1769394-1769675 [Microbacterium sp. PAMC22086]
VIRSFGNKDTERLWRRERVRSIDPRIHRVALRKLRQVGSAEVLDDLRIPPGNRLEALRGDRAGQHSIRINDQWRICFVWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T211835 NZ_CP106786:911413-911856 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11031.52 Da        Isoelectric Point: 4.8129

>AT211835 WP_044496365.1 NZ_CP080380:1769662-1769964 [Microbacterium sp. PAMC22086]
MTTTDRIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLARYFGTSAEFWINLQSHYEL
DRAEDAAGEQIAAIAPLQVA

Download         Length: 303 bp

>AT211835 NZ_CP106786:911186-911416 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References