Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 3085518..3086293 | Replicon | chromosome |
Accession | NZ_CP080369 | ||
Organism | Pseudomonas aeruginosa SG17M |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | V6ADY6 |
Locus tag | K0E51_RS14515 | Protein ID | WP_009518525.1 |
Coordinates | 3085835..3086293 (+) | Length | 153 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | A0A7M2ZSF3 |
Locus tag | K0E51_RS14510 | Protein ID | WP_023087286.1 |
Coordinates | 3085518..3085835 (+) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K0E51_RS14480 (K0E51_14460) | 3080842..3081492 | - | 651 | WP_023087281.1 | isoprenylcysteine carboxylmethyltransferase family protein | - |
K0E51_RS14485 (K0E51_14465) | 3081489..3081728 | - | 240 | WP_023087282.1 | DUF2933 domain-containing protein | - |
K0E51_RS14490 (K0E51_14470) | 3081740..3082141 | - | 402 | WP_023087283.1 | hypothetical protein | - |
K0E51_RS14495 | 3082296..3082730 | - | 435 | WP_078452152.1 | hypothetical protein | - |
K0E51_RS14500 (K0E51_14480) | 3082803..3083297 | + | 495 | WP_031633853.1 | MerR family DNA-binding protein | - |
K0E51_RS14505 (K0E51_14485) | 3083353..3085218 | - | 1866 | WP_023087285.1 | MobH family relaxase | - |
K0E51_RS14510 (K0E51_14490) | 3085518..3085835 | + | 318 | WP_023087286.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
K0E51_RS14515 (K0E51_14495) | 3085835..3086293 | + | 459 | WP_009518525.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
K0E51_RS14520 (K0E51_14500) | 3086320..3086679 | + | 360 | WP_023087287.1 | DUF3742 family protein | - |
K0E51_RS14525 (K0E51_14505) | 3086686..3088209 | - | 1524 | WP_023087288.1 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
K0E51_RS14530 (K0E51_14510) | 3088223..3088582 | - | 360 | WP_023087289.1 | hypothetical protein | - |
K0E51_RS14535 (K0E51_14515) | 3088579..3089973 | - | 1395 | WP_023087290.1 | integrating conjugative element protein | - |
K0E51_RS14540 (K0E51_14520) | 3089983..3090930 | - | 948 | WP_023087291.1 | TIGR03756 family integrating conjugative element protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | - | 3032231..3147438 | 115207 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 153 a.a. Molecular weight: 17660.02 Da Isoelectric Point: 10.1848
>T211789 WP_009518525.1 NZ_CP080369:3085835-3086293 [Pseudomonas aeruginosa SG17M]
MQRHGWTLLFHDCVIEQLQKLHAAARRAQENDPAGFESNANVKLFRALSQLMLDVVPGDPARDEYRQGNTLGPAHRHWRR
AKIGRRFRLFFRYDSKAKVIVYAWVNDEQTLRSSGSKSDPYVVFEKMLGRGNPPDDWHALIQASKQDWSKLE
MQRHGWTLLFHDCVIEQLQKLHAAARRAQENDPAGFESNANVKLFRALSQLMLDVVPGDPARDEYRQGNTLGPAHRHWRR
AKIGRRFRLFFRYDSKAKVIVYAWVNDEQTLRSSGSKSDPYVVFEKMLGRGNPPDDWHALIQASKQDWSKLE
Download Length: 459 bp
>T211789 NZ_CP106765:c1654160-1653978 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11156.69 Da Isoelectric Point: 4.5685
>AT211789 WP_023087286.1 NZ_CP080369:3085518-3085835 [Pseudomonas aeruginosa SG17M]
MPAIHEVATLTSKGQITLPKPIRQALGVDAGGKLAFDLRGSEVVVTRVDAEHEDPAIGAFLSLLARDIEAGRNLQGLPED
LARAMLEHAGHGVNLDEEIDGKVEL
MPAIHEVATLTSKGQITLPKPIRQALGVDAGGKLAFDLRGSEVVVTRVDAEHEDPAIGAFLSLLARDIEAGRNLQGLPED
LARAMLEHAGHGVNLDEEIDGKVEL
Download Length: 318 bp
>AT211789 NZ_CP106765:c1653876-1653475 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V6ADY6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7M2ZSF3 |