Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 354808..355448 Replicon chromosome
Accession NZ_CP080362
Organism Klebsiella pneumoniae strain K191773

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag K0P53_RS01640 Protein ID WP_016529833.1
Coordinates 354808..355155 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K0P53_RS01645 Protein ID WP_040181955.1
Coordinates 355155..355448 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P53_RS01630 (350734) 350734..352167 + 1434 WP_002920564.1 glycogen synthase GlgA -
K0P53_RS01635 (352185) 352185..354632 + 2448 WP_002920561.1 glycogen phosphorylase -
K0P53_RS01640 (354808) 354808..355155 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0P53_RS01645 (355155) 355155..355448 + 294 WP_040181955.1 helix-turn-helix transcriptional regulator Antitoxin
K0P53_RS01650 (355518) 355518..357026 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
K0P53_RS01655 (357231) 357231..357560 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
K0P53_RS01660 (357611) 357611..358441 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
K0P53_RS01665 (358491) 358491..359249 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T211764 WP_016529833.1 NZ_CP080362:354808-355155 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T211764 NZ_CP106757:419552-419653 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT211764 WP_040181955.1 NZ_CP080362:355155-355448 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp

>AT211764 NZ_CP106757:c419777-419590 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAACGCAACAAGGGTTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References