Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 355178..355818 Replicon chromosome
Accession NZ_CP080353
Organism Klebsiella pneumoniae strain K191663

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag K0P45_RS01645 Protein ID WP_016529833.1
Coordinates 355178..355525 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K0P45_RS01650 Protein ID WP_040181955.1
Coordinates 355525..355818 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P45_RS01635 (351104) 351104..352537 + 1434 WP_002920564.1 glycogen synthase GlgA -
K0P45_RS01640 (352555) 352555..355002 + 2448 WP_002920561.1 glycogen phosphorylase -
K0P45_RS01645 (355178) 355178..355525 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0P45_RS01650 (355525) 355525..355818 + 294 WP_040181955.1 helix-turn-helix transcriptional regulator Antitoxin
K0P45_RS01655 (355888) 355888..357396 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
K0P45_RS01660 (357601) 357601..357930 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
K0P45_RS01665 (357981) 357981..358811 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
K0P45_RS01670 (358861) 358861..359619 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T211745 WP_016529833.1 NZ_CP080353:355178-355525 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T211745 NZ_CP106756:c2210456-2210349 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT211745 WP_040181955.1 NZ_CP080353:355525-355818 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp

>AT211745 NZ_CP106756:2210503-2210569 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References