Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 328989..329575 Replicon chromosome
Accession NZ_CP080353
Organism Klebsiella pneumoniae strain K191663

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag K0P45_RS01535 Protein ID WP_023285605.1
Coordinates 329207..329575 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag K0P45_RS01530 Protein ID WP_004174006.1
Coordinates 328989..329210 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P45_RS01510 (325146) 325146..326072 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K0P45_RS01515 (326069) 326069..327346 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
K0P45_RS01520 (327343) 327343..328110 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
K0P45_RS01525 (328112) 328112..328825 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
K0P45_RS01530 (328989) 328989..329210 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K0P45_RS01535 (329207) 329207..329575 + 369 WP_023285605.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K0P45_RS01540 (329848) 329848..331164 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
K0P45_RS01545 (331271) 331271..332158 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
K0P45_RS01550 (332155) 332155..333000 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
K0P45_RS01555 (333002) 333002..334072 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 327343..334809 7466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13534.89 Da        Isoelectric Point: 8.6410

>T211744 WP_023285605.1 NZ_CP080353:329207-329575 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGITVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T211744 NZ_CP106756:c2209921-2209814 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGTTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT211744 WP_004174006.1 NZ_CP080353:328989-329210 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT211744 NZ_CP106756:2209968-2210034 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References