Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1241564..1242128 Replicon chromosome
Accession NZ_CP080336
Organism Lacticaseibacillus paracasei strain L1

Toxin (Protein)


Gene name yafQ Uniprot ID A0A6G9EML4
Locus tag KZR06_RS05840 Protein ID WP_014951859.1
Coordinates 1241826..1242128 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag KZR06_RS05835 Protein ID WP_003570051.1
Coordinates 1241564..1241833 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZR06_RS05805 (KZR06_05765) 1236905..1237792 - 888 WP_016385537.1 ABC transporter ATP-binding protein -
KZR06_RS05810 (KZR06_05770) 1237989..1239215 - 1227 WP_003574766.1 hypothetical protein -
KZR06_RS05815 (KZR06_05775) 1239413..1239817 + 405 WP_003574768.1 MerR family transcriptional regulator -
KZR06_RS05820 (KZR06_05780) 1239810..1240136 + 327 WP_003658351.1 YrdB family protein -
KZR06_RS05825 (KZR06_05785) 1240198..1240492 + 295 Protein_1118 hypothetical protein -
KZR06_RS05830 (KZR06_05790) 1240537..1241190 + 654 WP_003570049.1 N-acetyltransferase -
KZR06_RS05835 (KZR06_05795) 1241564..1241833 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KZR06_RS05840 (KZR06_05800) 1241826..1242128 + 303 WP_014951859.1 type II toxin-antitoxin system YafQ family toxin Toxin
KZR06_RS05845 (KZR06_05805) 1242467..1242610 + 144 WP_003574774.1 hypothetical protein -
KZR06_RS05850 (KZR06_05810) 1242837..1243424 + 588 WP_003574776.1 hypothetical protein -
KZR06_RS05855 (KZR06_05815) 1243660..1245837 + 2178 WP_016385304.1 Tex family protein -
KZR06_RS05860 (KZR06_05820) 1246012..1246449 - 438 WP_016385305.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11441.27 Da        Isoelectric Point: 10.2818

>T211720 WP_014951859.1 NZ_CP080336:1241826-1242128 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGDWLLIYKIK
QQDLILTLVRTGSHHNLLGK

Download         Length: 303 bp

>T211720 NZ_CP106750:2507-2785 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT211720 WP_003570051.1 NZ_CP080336:1241564-1241833 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT211720 NZ_CP106750:2322-2507 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9EML4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References