Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 355237..355883 | Replicon | chromosome |
Accession | NZ_CP080297 | ||
Organism | Klebsiella pneumoniae strain KP-C76 |
Toxin (Protein)
Gene name | higB | Uniprot ID | W8UNE1 |
Locus tag | K0E64_RS01635 | Protein ID | WP_002920560.1 |
Coordinates | 355237..355584 (+) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | W8UB68 |
Locus tag | K0E64_RS01640 | Protein ID | WP_002920557.1 |
Coordinates | 355584..355883 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K0E64_RS01625 (K0E64_01625) | 351163..352596 | + | 1434 | WP_002920564.1 | glycogen synthase GlgA | - |
K0E64_RS01630 (K0E64_01630) | 352614..355061 | + | 2448 | WP_002920561.1 | glycogen phosphorylase | - |
K0E64_RS01635 (K0E64_01635) | 355237..355584 | + | 348 | WP_002920560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K0E64_RS01640 (K0E64_01640) | 355584..355883 | + | 300 | WP_002920557.1 | helix-turn-helix transcriptional regulator | Antitoxin |
K0E64_RS01645 (K0E64_01645) | 355946..357454 | - | 1509 | WP_002920554.1 | glycerol-3-phosphate dehydrogenase | - |
K0E64_RS01650 (K0E64_01650) | 357659..357988 | + | 330 | WP_002920552.1 | thiosulfate sulfurtransferase GlpE | - |
K0E64_RS01655 (K0E64_01655) | 358039..358869 | + | 831 | WP_004151408.1 | rhomboid family intramembrane serine protease GlpG | - |
K0E64_RS01660 (K0E64_01660) | 358919..359677 | + | 759 | WP_002920548.1 | DeoR/GlpR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13502.56 Da Isoelectric Point: 6.2300
>T211616 WP_002920560.1 NZ_CP080297:355237-355584 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER
Download Length: 348 bp
>T211616 NZ_CP106654:c4625930-4625589 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATATCTGTCCCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATATCTGTCCCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10800.58 Da Isoelectric Point: 10.1464
>AT211616 WP_002920557.1 NZ_CP080297:355584-355883 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL
Download Length: 300 bp
>AT211616 NZ_CP106654:c4626277-4625951 [Klebsiella pneumoniae]
ATGTCATCAAATGACTTACAGCAATGGGGATTATGTCGCAGCATCTCACCGTGCTTTGGCGCAAGGCTCGTACAGGAGAG
AAACCGCCTGCACTTTCTAGCTGACCGCGCCGGTTTTAACGGTCAGTTTACCGAAGAGCAGGCGCTGCGACTCGATCAGG
CATTTCCTCTGATTATGAAGCAACTCGAGCTTATGCTCTCCACCGGTGAGCTAAATCCGCGCCACTCGCATTGTGTCACC
CTTTACCACAATGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCA
TCGTTAA
ATGTCATCAAATGACTTACAGCAATGGGGATTATGTCGCAGCATCTCACCGTGCTTTGGCGCAAGGCTCGTACAGGAGAG
AAACCGCCTGCACTTTCTAGCTGACCGCGCCGGTTTTAACGGTCAGTTTACCGAAGAGCAGGCGCTGCGACTCGATCAGG
CATTTCCTCTGATTATGAAGCAACTCGAGCTTATGCTCTCCACCGGTGAGCTAAATCCGCGCCACTCGCATTGTGTCACC
CTTTACCACAATGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCA
TCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E1CBY5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E1CBF8 |