Detailed information of TA system TA211597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2353873..2354554
• Replicon: chromosome
• Accession: NZ_CP080288
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF05

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KZ800_RS10820
• Protein ID: WP_015503432.1
• Coordinates: 2353873..2354238 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KZ800_RS10825
• Protein ID: WP_003145733.1
• Coordinates: 2354231..2354554 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ800_RS10790 (KZ800_10795)	2349867..2350277	-	411	WP_134617503.1	RidA family protein	-
KZ800_RS10795 (KZ800_10800)	2350523..2351476	+	954	WP_003085661.1	LysR substrate-binding domain-containing protein	-
KZ800_RS10800 (KZ800_10805)	2351449..2352333	-	885	WP_003085663.1	LysR substrate-binding domain-containing protein	-
KZ800_RS10805 (KZ800_10810)	2352435..2352860	+	426	WP_003085665.1	VOC family protein	-
KZ800_RS10810 (KZ800_10815)	2352891..2353163	-	273	WP_023104842.1	hypothetical protein	-
KZ800_RS10815 (KZ800_10820)	2353370..2353609	+	240	WP_044060930.1	hypothetical protein	-
KZ800_RS10820 (KZ800_10825)	2353873..2354238	+	366	WP_015503432.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ800_RS10825 (KZ800_10830)	2354231..2354554	+	324	WP_003145733.1	XRE family transcriptional regulator	Antitoxin
KZ800_RS10830 (KZ800_10835)	2354930..2356018	-	1089	WP_030046797.1	DUF3396 domain-containing protein	-
KZ800_RS10835 (KZ800_10840)	2356035..2356736	-	702	WP_030046795.1	VRR-NUC domain-containing protein	-
KZ800_RS10840 (KZ800_10845)	2356733..2357251	-	519	WP_010793873.1	PAAR domain-containing protein	-
KZ800_RS10845 (KZ800_10850)	2357425..2357760	-	336	WP_003119438.1	TM2 domain-containing protein	-
KZ800_RS10850 (KZ800_10855)	2358003..2358641	-	639	WP_003119439.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-63)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13798.14 Da
• Isoelectric Point: 4.8219

>T211597 WP_015503432.1 NZ_CP080288:2353873-2354238 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Nucleotide

• Length: 366 bp

>T211597 NZ_CP104991:c146137-145640 [Rhizobium sp. CC-CFT758]
GTGACCCTCACTTCCCCTGCTCCTTTGGCCGAGCATCATGAGCTTGTCGAATTTGATTCCGGCGTTCCGGAGCTAGATGA
CTGGCTGCGTCGACGAGCGCGAGCCAATCAGGCGGGCGGTGCGTCTCGTACCTTCGTGGTCTGCGACGGAAATCGCGTCG
TTGCCTATTACGCTCTCGCCTCTGGCGCGGTGAGGACGCCAGAAGCACCAGGGCGCCTTAAGCGAAACATGCCAGATCCG
ATCCCAGTCGCCGTACTTGGTCGACTGGCTATAGACCTGTCTCATCAGGGCCGCGGTATTGGTCGAGCTTTGGTGCGCGA
TGCCGGCCTGCGTCTGCTCAATGCCGCGGAGATCCTCGGTATCCGTGGCGTGCTGGTGCATGCCATATCCGATGACGCAC
GTGCCTTCTATGAAGCCGTTGGATTTCTACCGTCTCCGTCCGACCCGATGATGCTGATGATTGGATTGAAAGATCTCATC
AACGCAGTGAACGCATAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11896.73 Da
• Isoelectric Point: 6.4751

>AT211597 WP_003145733.1 NZ_CP080288:2354231-2354554 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Nucleotide

• Length: 324 bp

>AT211597 NZ_CP104991:c146430-146134 [Rhizobium sp. CC-CFT758]
ATGCCGACGTCACATACTCGCAAAAATGTGGACGCAAGTGTTCCACTGAACATCCGTATCAAACCCGCGACGCGCAATCT
CATCGACCGCGCGGCTGAACTGCTTGGCAAGACGCGGACGGATTTCATGCTGGAGGCGTCTGAACGCCGCGCCGAGGAAG
TGCTGCTTGACCGTACCGTATTCACGGTCAGCCCGGAGGCCTATGCCGAATACCTAGCCCGGCTCGATGCGCCAGCGCAG
CTGAATGAGCGTCTGAAACGCACAATGTCGACTAAAGCTCCATGGGATAAGGCGTGA