211596

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1741580..1742175 Replicon chromosome
Accession NZ_CP080288
Organism Pseudomonas aeruginosa strain UNC_PaerCF05

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KZ800_RS08025 Protein ID WP_219832885.1
Coordinates 1741580..1741858 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KZ800_RS08030 Protein ID WP_003113527.1
Coordinates 1741870..1742175 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ800_RS08010 (KZ800_08015) 1737005..1738244 + 1240 Protein_1580 dipeptidase -
KZ800_RS08015 (KZ800_08020) 1738306..1738953 + 648 WP_003095021.1 carbonate dehydratase -
KZ800_RS08020 (KZ800_08025) 1739023..1741251 - 2229 WP_004352671.1 TonB-dependent receptor -
KZ800_RS28415 1741399..1741527 + 129 Protein_1583 integrase -
KZ800_RS08025 (KZ800_08030) 1741580..1741858 + 279 WP_219832885.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ800_RS08030 (KZ800_08035) 1741870..1742175 + 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
KZ800_RS08040 (KZ800_08045) 1742584..1743684 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
KZ800_RS08045 (KZ800_08050) 1743725..1744309 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
KZ800_RS08050 (KZ800_08055) 1744351..1744965 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
KZ800_RS08055 (KZ800_08060) 1745082..1746023 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
KZ800_RS08065 (KZ800_08070) 1746190..1747038 - 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10671.25 Da        Isoelectric Point: 9.3867

>T211596 WP_219832885.1 NZ_CP080288:1741580-1741858 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRRGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T211596 NZ_CP104991:c144591-144298 [Rhizobium sp. CC-CFT758]
ATGCCGTTTAGCCTTTCAGCCCAAGCGGAAGAGGACATTGTGTCCATTGCTGAAGAGGGCATCCACGTCTTCGGAGCATT
TGTCGCCAAACGCTATCATGACGAACTTTTTGCCTTATTCGAACTCATCGCCGCGAACCCGCGAATGGCGCGCGGACGCG
ATGAGATTTCTCCGCCTGTCAGGATACATCCCTTCAAAGCTCACCTTGTAGTCTATCGCCTCATCGAAGATGGAGGCGTT
TTCGTGATCCGTATCCGGAACAGTCATGAAGATTGGGCAGGAGATTCCTTTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT211596 WP_003113527.1 NZ_CP080288:1741870-1742175 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT211596 NZ_CP104991:c144845-144591 [Rhizobium sp. CC-CFT758]
ATGGCGACGATGAATGTATCACTGCCGGACCCTATGAAGGATTGGGTTGAAGCACAAGCCAAGACGGGTCGGTATTCAAA
TGTAAGCGACTATGTCAGAGATCTGATCCGGAGAGACCAGACCCGCACAGACAAGATTGCCGAGATGCAGCGCTTTGTCG
ACGACGGGATCGCAAGTGGAGTTGGGAACCGTTCAGGTGACCAACTGTTTGCAGAAGCGACCGCGCGAGCCGATGTCAAC
CGCAGACGCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References