Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 223486..224081 Replicon chromosome
Accession NZ_CP080286
Organism Pseudomonas aeruginosa strain UNC_PaerCF12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KZ795_RS01035 Protein ID WP_079752024.1
Coordinates 223803..224081 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KZ795_RS01030 Protein ID WP_033971055.1
Coordinates 223486..223791 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ795_RS00995 (KZ795_00995) 218638..219486 + 849 WP_033971048.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
KZ795_RS01005 (KZ795_01005) 219653..220594 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
KZ795_RS01010 (KZ795_01010) 220711..221325 + 615 WP_033971050.1 50S ribosomal protein L25/general stress protein Ctc -
KZ795_RS01015 (KZ795_01015) 221367..221951 + 585 WP_033971054.1 aminoacyl-tRNA hydrolase -
KZ795_RS01020 (KZ795_01020) 221992..223092 + 1101 WP_058178912.1 redox-regulated ATPase YchF -
KZ795_RS01030 (KZ795_01030) 223486..223791 - 306 WP_033971055.1 HigA family addiction module antitoxin Antitoxin
KZ795_RS01035 (KZ795_01035) 223803..224081 - 279 WP_079752024.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ795_RS01040 (KZ795_01040) 224134..224366 - 233 Protein_200 tyrosine-type recombinase/integrase -
KZ795_RS01045 (KZ795_01045) 224735..224938 + 204 WP_033971061.1 hypothetical protein -
KZ795_RS01050 (KZ795_01050) 225336..225851 - 516 WP_083556826.1 BRO family protein -
KZ795_RS01055 (KZ795_01055) 226158..226808 - 651 WP_033971066.1 carbonate dehydratase -
KZ795_RS01060 (KZ795_01060) 226870..228108 - 1239 WP_033971069.1 C69 family dipeptidase -
KZ795_RS01065 (KZ795_01065) 228307..228759 - 453 WP_003095025.1 ribosomal protein S18-alanine N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10673.26 Da        Isoelectric Point: 8.5538

>T211589 WP_079752024.1 NZ_CP080286:c224081-223803 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAAKELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T211589 NZ_CP104976:1871782-1871885 [Enterobacter sp. 155105]
GGCAGGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11230.69 Da        Isoelectric Point: 4.4462

>AT211589 WP_033971055.1 NZ_CP080286:c223791-223486 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPTALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT211589 NZ_CP104976:c1871890-1871747 [Enterobacter sp. 155105]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCCTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References