Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3539696..3540326 Replicon chromosome
Accession NC_006513
Organism Aromatoleum aromaticum EbN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EB_RS16650 Protein ID WP_041646539.1
Coordinates 3539696..3540022 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EB_RS16655 Protein ID WP_011239183.1
Coordinates 3540015..3540326 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB_RS24375 3535298..3535459 + 162 WP_157866643.1 hypothetical protein -
EB_RS16610 3535475..3535828 + 354 WP_011239175.1 VanZ family protein -
EB_RS16615 3535883..3537106 + 1224 WP_011237251.1 ISAzo13-like element ISAzo13 family transposase -
EB_RS16620 3537440..3537784 + 345 WP_011239177.1 DUF86 domain-containing protein -
EB_RS16625 3537774..3538160 - 387 WP_041646537.1 type II toxin-antitoxin system VapC family toxin -
EB_RS16630 3538157..3538405 - 249 WP_041646538.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EB_RS16635 3538575..3538910 + 336 WP_011239179.1 H-NS histone family protein -
EB_RS16640 3538891..3539370 + 480 WP_011239180.1 VanZ family protein -
EB_RS16645 3539385..3539651 + 267 WP_011239181.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
EB_RS16650 3539696..3540022 + 327 WP_041646539.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EB_RS16655 3540015..3540326 + 312 WP_011239183.1 helix-turn-helix domain-containing protein Antitoxin
EB_RS22970 3540487..3540660 + 174 WP_197531823.1 hypothetical protein -
EB_RS16670 3541039..3541326 + 288 WP_041646540.1 DUF1778 domain-containing protein -
EB_RS23440 3541311..3541814 + 504 WP_197531824.1 GNAT family N-acetyltransferase -
EB_RS16675 3541898..3542188 + 291 WP_011239187.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EB_RS16680 3542188..3542625 + 438 WP_011239188.1 putative toxin-antitoxin system toxin component, PIN family -
EB_RS16685 3542831..3543169 + 339 WP_011239189.1 H-NS histone family protein -
EB_RS16690 3543355..3543606 + 252 WP_011239190.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EB_RS16695 3543515..3543922 + 408 Protein_3311 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-98)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12707.79 Da        Isoelectric Point: 9.5805

>T21155 WP_041646539.1 NC_006513:3539696-3540022 [Aromatoleum aromaticum EbN1]
MNWTVSYFNERVREEITKWPVGIYADFLRLIFLMEEHGADLRLPHSRAMGDGLFELRCKGEEGIGRVFYCTLVGRQIVIL
HSFIKKTQETPDRELKTARKRLKEVKHG

Download         Length: 327 bp

>T21155 NC_006513:3539696-3540022 [Aromatoleum aromaticum EbN1]
ATGAACTGGACAGTCAGTTACTTCAACGAGCGCGTGCGGGAGGAAATCACCAAATGGCCAGTCGGCATCTACGCTGACTT
CCTGCGCCTCATCTTCCTGATGGAAGAGCACGGTGCTGACCTGCGCCTGCCGCACTCTCGCGCCATGGGCGATGGCCTCT
TCGAGCTGCGCTGCAAGGGTGAGGAAGGAATTGGCCGAGTGTTCTACTGCACGTTGGTCGGACGCCAGATCGTCATCCTG
CACAGCTTCATCAAAAAGACGCAGGAAACTCCAGACCGGGAGCTGAAGACTGCCCGCAAGCGACTGAAGGAGGTCAAACA
TGGATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11516.26 Da        Isoelectric Point: 10.2119

>AT21155 WP_011239183.1 NC_006513:3540015-3540326 [Aromatoleum aromaticum EbN1]
MDKEHFKPVRLDTKAELARAMQRPGFKAAWDGLEEEYAALNELLQARKQAGLTQEEVAARMGTTKSAVSRLEASIRSESH
SPSFATLRKYAHACGKRLVIKMV

Download         Length: 312 bp

>AT21155 NC_006513:3540015-3540326 [Aromatoleum aromaticum EbN1]
ATGGATAAAGAGCATTTCAAGCCGGTTCGCCTGGACACCAAGGCCGAACTTGCCCGTGCCATGCAACGGCCGGGATTCAA
GGCTGCGTGGGACGGACTGGAGGAAGAGTACGCGGCACTCAACGAGCTGCTCCAGGCGCGCAAGCAAGCCGGCCTGACGC
AGGAAGAAGTCGCTGCGCGCATGGGCACGACCAAGAGCGCCGTGTCGCGTCTGGAAGCATCCATTCGTAGCGAAAGCCAT
TCGCCCTCGTTCGCCACGCTGCGCAAGTACGCACACGCCTGCGGCAAGCGACTGGTCATCAAGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References