211540

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3570817..3571319 Replicon chromosome
Accession NZ_CP080260
Organism Escherichia coli strain 135

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag KZ312_RS17280 Protein ID WP_000767820.1
Coordinates 3570817..3571071 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag KZ312_RS17285 Protein ID WP_001259255.1
Coordinates 3571068..3571319 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ312_RS17260 (3567310) 3567310..3568668 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
KZ312_RS17265 (3568658) 3568658..3568720 - 63 WP_010723108.1 membrane protein YoeI -
KZ312_RS17270 (3568935) 3568935..3569864 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
KZ312_RS17275 (3569910) 3569910..3570734 - 825 WP_086795454.1 SDR family oxidoreductase -
KZ312_RS17280 (3570817) 3570817..3571071 - 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
KZ312_RS17285 (3571068) 3571068..3571319 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KZ312_RS17290 (3571603) 3571603..3571653 + 51 WP_001364200.1 his operon leader peptide -
KZ312_RS17295 (3571799) 3571799..3572698 + 900 WP_000131789.1 ATP phosphoribosyltransferase -
KZ312_RS17300 (3572704) 3572704..3574008 + 1305 WP_001306412.1 histidinol dehydrogenase -
KZ312_RS17305 (3574005) 3574005..3575075 + 1071 WP_000108970.1 histidinol-phosphate transaminase -
KZ312_RS17310 (3575075) 3575075..3576142 + 1068 WP_000080071.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T211540 WP_000767820.1 NZ_CP080260:c3571071-3570817 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T211540 NZ_CP104920:2511190-2511669 [Dickeya solani]
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCGGTTGTGGATTTTCACTGTTCAGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAGGCGTTAAAAAATCAGACGCTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGTACACAAC
GTGTGGTGGGGTTCTATGCCCTCGCTTCGGGTAGCATCCAACGTCAGGTTGCACCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTGCTTGGCCGATTAGCCGTTGATGAACGTTATCAACGTATGGGGATCGGTGCAGGACTTCT
GAAAGATGCGGTACTCCGCTCCCGTAATGTAGCGCAGCAGGTAGGCAACAAAGCGTTATTGGTACATGCGTTATCTGATG
AAGCAAAAGCGTTCTACCAATACTGGGGTTTTGTCCCATCAGAAATACAAGAACACACCTTATTATTATCGTTATGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT211540 WP_001259255.1 NZ_CP080260:c3571319-3571068 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT211540 NZ_CP104920:2510927-2511199 [Dickeya solani]
ATGCGAACAGAGACAAAAGAAATGCCGATTAATATTCGTGCTAAAGCATCACAGCGAGAGCTGATTGATGTCGCCGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAGGATGTGTTGTTGGATCAAAGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGCTGGAATCACCTGTCACAGATAATCCGCGTGTGAAT
GCGTTACTGAACAGGAAATCTCCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References