Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 2831357..2831728 | Replicon | chromosome |
| Accession | NZ_CP080260 | ||
| Organism | Escherichia coli strain 135 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A839BBC2 |
| Locus tag | KZ312_RS13580 | Protein ID | WP_021500490.1 |
| Coordinates | 2831534..2831728 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 2831357..2831535 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZ312_RS13555 (2827312) | 2827312..2828685 | + | 1374 | WP_086795298.1 | ATP-dependent RNA helicase DbpA | - |
| KZ312_RS13560 (2828814) | 2828814..2829749 | - | 936 | WP_001157382.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| KZ312_RS13565 (2829801) | 2829801..2831036 | - | 1236 | WP_086795299.1 | site-specific integrase | - |
| KZ312_RS13570 (2831038) | 2831038..2831253 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (2831357) | 2831357..2831535 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2831357) | 2831357..2831535 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2831357) | 2831357..2831535 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2831357) | 2831357..2831535 | + | 179 | NuclAT_0 | - | Antitoxin |
| KZ312_RS13575 (2831353) | 2831353..2831541 | - | 189 | WP_001298826.1 | DUF1187 family protein | - |
| KZ312_RS13580 (2831534) | 2831534..2831728 | - | 195 | WP_021500490.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| KZ312_RS13585 (2831792) | 2831792..2832844 | - | 1053 | WP_001004422.1 | RecT family recombinase | - |
| KZ312_RS13590 (2832856) | 2832856..2835978 | - | 3123 | WP_016248739.1 | exodeoxyribonuclease VIII | - |
| KZ312_RS13595 (2836080) | 2836080..2836355 | - | 276 | WP_016248738.1 | phage protein | - |
| KZ312_RS13600 (2836430) | 2836430..2836600 | - | 171 | WP_077688178.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2829801..2877059 | 47258 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7046.98 Da Isoelectric Point: 9.2886
>T211524 WP_021500490.1 NZ_CP080260:c2831728-2831534 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T211524 NZ_CP104913:c5242849-5242571 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 179 bp
>AT211524 NZ_CP080260:2831357-2831535 [Escherichia coli]
GAGGACTGAAGTTGCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTGCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
