Detailed information of TA system TA211500

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 151754..152023
• Replicon: plasmid pSJC33-1
• Accession: NZ_CP080256
• Organism: Escherichia coli strain SJC33

Toxin (Protein)

• Gene name: hok
• Uniprot ID: G9G195
• Locus tag: KZ313_RS23725
• Protein ID: WP_001323520.1
• Coordinates: 151907..152023 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	151754..151819 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ313_RS25530	146823..147071	+	249	WP_071606928.1	hypothetical protein	-
KZ313_RS23695	147544..148071	+	528	WP_133303330.1	single-stranded DNA-binding protein	-
KZ313_RS23700	148129..148362	+	234	WP_000005985.1	DUF905 family protein	-
KZ313_RS23705	148421..150379	+	1959	WP_001145462.1	ParB/RepB/Spo0J family partition protein	-
KZ313_RS23710	150434..150869	+	436	Protein_168	conjugation system SOS inhibitor PsiB	-
KZ313_RS23715	150866..151628	+	763	Protein_169	plasmid SOS inhibition protein A	-
KZ313_RS23720	151597..151785	-	189	WP_219805971.1	protein sok	-
-	151597..151821	+	225	NuclAT_1	-	-
-	151597..151821	+	225	NuclAT_1	-	-
-	151597..151821	+	225	NuclAT_1	-	-
-	151597..151821	+	225	NuclAT_1	-	-
-	151754..151819	-	66	-	-	Antitoxin
KZ313_RS25535	151807..151956	+	150	Protein_171	plasmid maintenance protein Mok	-
KZ313_RS23725	151907..152023	+	117	WP_001323520.1	type I toxin-antitoxin system Hok family toxin	Toxin
KZ313_RS25540	152241..152471	+	231	WP_071587244.1	hypothetical protein	-
KZ313_RS25545	152469..152641	-	173	Protein_174	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-34)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4455.23 Da
• Isoelectric Point: 8.5110

>T211500 WP_001323520.1 NZ_CP080256:151907-152023 [Escherichia coli]
VCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 117 bp

>T211500 NZ_CP104882:c1438650-1438360 [Aggregatibacter actinomycetemcomitans]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGCAAAAGTTAGGCGATACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCGGGCGACAAATTAAGAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAGACGCATACAAAAATGCAGAATTCAGACAAGCTCGGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT211500 NZ_CP080256:c151819-151754 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Toxin

• AlphaFold DB: G9G195

Antitoxin