Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1518360..1518948 Replicon chromosome
Accession NC_006513
Organism Aromatoleum aromaticum EbN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EB_RS07115 Protein ID WP_041645963.1
Coordinates 1518360..1518638 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag EB_RS07120 Protein ID WP_011237269.1
Coordinates 1518649..1518948 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB_RS07090 1513779..1514123 - 345 Protein_1404 disulfide bond formation protein DsbA -
EB_RS23995 1514185..1515570 + 1386 WP_011237263.1 hypothetical protein -
EB_RS07100 1515572..1516321 - 750 WP_011237264.1 TIGR03747 family integrating conjugative element membrane protein -
EB_RS07105 1516318..1517016 - 699 Protein_1407 TraM recognition domain-containing protein -
EB_RS07110 1517576..1518265 + 690 WP_011237267.1 transposase -
EB_RS07115 1518360..1518638 + 279 WP_041645963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EB_RS07120 1518649..1518948 + 300 WP_011237269.1 HigA family addiction module antidote protein Antitoxin
EB_RS07125 1519134..1519826 + 693 WP_011237270.1 SDR family oxidoreductase -
EB_RS07130 1519912..1520583 + 672 WP_157866591.1 transglutaminase family protein -
EB_RS07135 1520724..1522691 - 1968 WP_011237272.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1522735..1523958 1223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10236.72 Da        Isoelectric Point: 9.7361

>T21147 WP_041645963.1 NC_006513:1518360-1518638 [Aromatoleum aromaticum EbN1]
MIKSFRHKGIEAFFRTGSKAGITATHVGRLARQLALLNEATHPGHMDVPGWKLHPLAGSLKGHWAVLVSGNWRLTFAFEG
EDAVLVDYQDYH

Download         Length: 279 bp

>T21147 NC_006513:1518360-1518638 [Aromatoleum aromaticum EbN1]
ATGATAAAGAGCTTTCGCCACAAAGGGATCGAAGCTTTCTTCAGGACGGGCAGCAAGGCCGGAATCACCGCCACGCACGT
CGGCCGGCTGGCCCGCCAACTGGCCCTGCTGAACGAGGCGACCCATCCTGGACACATGGACGTGCCCGGTTGGAAGCTGC
ATCCGCTGGCAGGCAGCCTGAAGGGTCACTGGGCCGTGTTGGTCAGCGGGAACTGGCGCCTGACCTTCGCATTCGAGGGC
GAGGATGCCGTGCTCGTCGACTATCAGGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10910.63 Da        Isoelectric Point: 10.5822

>AT21147 WP_011237269.1 NC_006513:1518649-1518948 [Aromatoleum aromaticum EbN1]
MAPMYNPPHPGETLREDILPALGLTVSEAARQLGISRVQLSRVLHGRAPVSPDLALRLEQWLSGPTADIWLRMQIAYDLW
QARHGGSLPRVAPAQRKAA

Download         Length: 300 bp

>AT21147 NC_006513:1518649-1518948 [Aromatoleum aromaticum EbN1]
ATGGCACCGATGTACAACCCACCCCATCCCGGCGAAACCCTGCGCGAGGATATCCTGCCAGCGCTCGGCCTGACGGTGTC
CGAGGCCGCCCGCCAGCTGGGCATTTCCCGGGTCCAGCTTTCCCGCGTATTGCACGGGCGCGCACCCGTATCGCCCGACC
TGGCGCTGCGCCTCGAACAATGGCTGAGCGGGCCGACAGCCGACATTTGGTTGCGCATGCAGATCGCTTACGATTTGTGG
CAGGCGCGGCACGGTGGAAGTCTGCCTCGCGTCGCGCCAGCGCAGCGGAAGGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References