Detailed information of TA system TA211448

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2472048..2472232
• Replicon: chromosome
• Accession: NZ_CP080251
• Organism: Staphylococcus aureus strain NT_611

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KZZ50_RS12405
• Protein ID: WP_000482647.1
• Coordinates: 2472125..2472232 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2472048..2472108 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZZ50_RS12390	2467578..2467745	-	168	WP_001792506.1	hypothetical protein	-
KZZ50_RS12395	2467976..2469709	-	1734	WP_000486491.1	ABC transporter ATP-binding protein	-
KZZ50_RS12400	2469734..2471497	-	1764	WP_001064816.1	ABC transporter ATP-binding protein	-
-	2472048..2472108	+	61	-	-	Antitoxin
KZZ50_RS12405	2472125..2472232	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KZZ50_RS12410	2472366..2472752	-	387	WP_000779347.1	flippase GtxA	-
KZZ50_RS12415	2473010..2474152	+	1143	WP_072519225.1	glycerate kinase	-
KZZ50_RS12420	2474212..2474871	+	660	WP_000831298.1	membrane protein	-
KZZ50_RS12425	2475053..2476264	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KZZ50_RS12430	2476387..2476860	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T211448 WP_000482647.1 NZ_CP080251:c2472232-2472125 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T211448 NZ_CP104866:285178-285504 [Pseudomonas aeruginosa]
ATGAATGACCCCGTGTACTGCCCGGTTCTTGGGTATGACGCGGTGTTGCTTGTCAACATCTCGACTGTCTATCCAGATAA
GTATTTCGATCAGTCATGCATTCTAAAGAAGGGTTGTCATCCCTTTGTTCTGCACGACAGCTGGGTCGTATACCGCGAGG
CAGGCCCTTTCAACCTTGCACGGCTTGAGCAAGGGGTAGCGCAGAAGTCCATCAAGACGCATCAGCCCATCAACGCAGGC
GATTTCACTCGGATTCGGGCAGGCTTCGACATCTCGCCCGACGTCAAAATCAAAGTTGAGCGGTTCATGAGGCAGCACAA
GATTTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT211448 NZ_CP080251:2472048-2472108 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin