Detailed information of TA system TA211447

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 2191023..2191220
• Replicon: chromosome
• Accession: NZ_CP080251
• Organism: Staphylococcus aureus strain NT_611

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KZZ50_RS10940
• Protein ID: WP_001802298.1
• Coordinates: 2191116..2191220 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2191023..2191061 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZZ50_RS10915	2187210..2187875	-	666	WP_001024089.1	SDR family oxidoreductase	-
KZZ50_RS10920	2188027..2188347	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KZZ50_RS10925	2188349..2189326	+	978	WP_000019733.1	CDF family zinc efflux transporter CzrB	-
KZZ50_RS10930	2189592..2190683	+	1092	WP_000495669.1	hypothetical protein	-
KZZ50_RS10935	2191003..2191077	+	75	Protein_2119	hypothetical protein	-
-	2191023..2191061	+	39	-	-	Antitoxin
KZZ50_RS10940	2191116..2191220	-	105	WP_001802298.1	hypothetical protein	Toxin
KZZ50_RS10945	2191900..2192058	+	159	WP_001792784.1	hypothetical protein	-
KZZ50_RS10950	2192716..2193573	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
KZZ50_RS10955	2193641..2194423	-	783	WP_000908185.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T211447 WP_001802298.1 NZ_CP080251:c2191220-2191116 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T211447 NZ_CP104866:c146983-146702 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCATAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT211447 NZ_CP080251:2191023-2191061 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin