Detailed information of TA system TA211435

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1541197..1541776
• Replicon: chromosome
• Accession: NZ_CP080251
• Organism: Staphylococcus aureus strain NT_611

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: KZZ50_RS07405
• Protein ID: WP_001025401.1
• Coordinates: 1541531..1541776 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1541197..1541562 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZZ50_RS07365 (1537941)	1537941..1538498	-	558	WP_000645042.1	DUF2815 family protein	-
KZZ50_RS07370 (1538524)	1538524..1539690	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
KZZ50_RS07375 (1539687)	1539687..1540049	-	363	WP_000279445.1	hypothetical protein	-
KZZ50_RS07380 (1540064)	1540064..1540387	-	324	WP_000174995.1	hypothetical protein	-
KZZ50_RS07385 (1540466)	1540466..1540627	-	162	WP_015986189.1	DUF1270 family protein	-
KZZ50_RS07390 (1540639)	1540639..1540902	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
KZZ50_RS07395 (1540927)	1540927..1541142	-	216	WP_001097552.1	hypothetical protein	-
KZZ50_RS07400 (1541197)	1541197..1541562	+	366	WP_001128433.1	hypothetical protein	Antitoxin
KZZ50_RS07405 (1541531)	1541531..1541776	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
KZZ50_RS07410 (1541805)	1541805..1542581	-	777	WP_072519170.1	Rha family transcriptional regulator	-
KZZ50_RS07415 (1542595)	1542595..1542831	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
KZZ50_RS07420 (1542983)	1542983..1543297	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
KZZ50_RS07425 (1543310)	1543310..1543771	+	462	WP_072519171.1	toxin	-
KZZ50_RS07430 (1543788)	1543788..1544372	+	585	WP_072519172.1	hypothetical protein	-
KZZ50_RS07435 (1544602)	1544602..1544748	+	147	WP_001013104.1	hypothetical protein	-
KZZ50_RS07440 (1544745)	1544745..1545359	-	615	WP_000191457.1	hypothetical protein	-
KZZ50_RS07445 (1545485)	1545485..1546690	+	1206	WP_000264747.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1500698..1564327	63629

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T211435 WP_001025401.1 NZ_CP080251:c1541776-1541531 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T211435 NZ_CP104861:c4918112-4917825 [Pseudomonas fragi]
ATGCGAGTGATAACAGCCAAGCGTATTTGGGAAGCGAAAGAACAATGGCCGCAATCGGCGAACGCTCTTGATGAGTGGTA
TCGCAAGATCAAGGTCCTCAACCCTGAAGACTTTGCCGCGTTAAGGTCGTTTTTCCCAGCCACCGACAAGGTAGGTTCGT
TTCACGTTTTCAATATGGGAGGTAACAAGCTGCGGCTGATTGCCCTGGTGCGTTATCGGGTACAGCGCCTCTACATTCGT
CATGTGCTGGATCACCGTGACTATGACAAGGGCAACTGGAAGGAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT211435 NZ_CP080251:1541197-1541562 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin