Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2599203..2599720 Replicon chromosome
Accession NZ_CP080249
Organism Staphylococcus aureus strain NV_1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag KZW86_RS13230 Protein ID WP_000113265.1
Coordinates 2599203..2599469 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KZW86_RS13235 Protein ID WP_000584499.1
Coordinates 2599469..2599720 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW86_RS13200 (2594631) 2594631..2595167 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KZW86_RS13205 (2595401) 2595401..2596225 - 825 WP_000572038.1 formate/nitrite transporter family protein -
KZW86_RS13210 (2596442) 2596442..2596624 - 183 WP_000230292.1 hypothetical protein -
KZW86_RS13215 (2596708) 2596708..2597175 - 468 WP_000153347.1 SRPBCC domain-containing protein -
KZW86_RS13220 (2597361) 2597361..2598908 - 1548 WP_000727774.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KZW86_RS13225 (2599097) 2599097..2599168 - 72 Protein_2563 hypothetical protein -
KZW86_RS13230 (2599203) 2599203..2599469 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
KZW86_RS13235 (2599469) 2599469..2599720 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KZW86_RS13240 (2599885) 2599885..2599965 - 81 WP_223197974.1 hypothetical protein -
KZW86_RS13245 (2599993) 2599993..2600592 - 600 WP_000162810.1 DsbA family protein -
KZW86_RS13250 (2600611) 2600611..2600973 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KZW86_RS13255 (2601228) 2601228..2602478 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
KZW86_RS13260 (2602575) 2602575..2603306 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KZW86_RS13265 (2603303) 2603303..2604022 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T211429 WP_000113265.1 NZ_CP080249:c2599469-2599203 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T211429 NZ_CP104858:3860613-3860716 [Salmonella sp. 3C]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT211429 WP_000584499.1 NZ_CP080249:c2599720-2599469 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT211429 NZ_CP104858:c3860718-3860573 [Salmonella sp. 3C]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References