Detailed information of TA system TA211419

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2146745..2146970
• Replicon: chromosome
• Accession: NZ_CP080249
• Organism: Staphylococcus aureus strain NV_1

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: KZW86_RS10785
• Protein ID: WP_000253687.1
• Coordinates: 2146863..2146970 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2146745..2146838 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZW86_RS10760 (2142183)	2142183..2143136	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
KZW86_RS10765 (2143813)	2143813..2144553	-	741	WP_000185611.1	type II CAAX endopeptidase family protein	-
KZW86_RS10770 (2144898)	2144898..2146352	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
KZW86_RS10775 (2146363)	2146363..2146665	-	303	WP_000387655.1	phage holin	-
KZW86_RS10780 (2146716)	2146716..2146823	+	108	Protein_2087	hypothetical protein	-
- (2146745)	2146745..2146838	+	94	NuclAT_1	-	Antitoxin
- (2146745)	2146745..2146838	+	94	NuclAT_1	-	Antitoxin
- (2146745)	2146745..2146838	+	94	NuclAT_1	-	Antitoxin
- (2146745)	2146745..2146838	+	94	NuclAT_1	-	Antitoxin
KZW86_RS10785 (2146863)	2146863..2146970	-	108	WP_000253687.1	putative holin-like toxin	Toxin
KZW86_RS10790 (2147204)	2147204..2147503	-	300	WP_000466781.1	DUF2951 family protein	-
KZW86_RS10795 (2147549)	2147549..2147713	-	165	WP_000916020.1	XkdX family protein	-
KZW86_RS10800 (2147706)	2147706..2148095	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
KZW86_RS10805 (2148095)	2148095..2149561	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
KZW86_RS10810 (2149561)	2149561..2151471	-	1911	WP_000429548.1	hypothetical protein	-
KZW86_RS10815 (2151487)	2151487..2151777	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2144898..2197154	52256

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3844.80 Da
• Isoelectric Point: 10.4997

>T211419 WP_000253687.1 NZ_CP080249:c2146970-2146863 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLNHKK

Nucleotide

• Length: 108 bp

>T211419 NZ_CP104858:c1433247-1432879 [Salmonella sp. 3C]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGAGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Nucleotide

• Length: 94 bp

>AT211419 NZ_CP080249:2146745-2146838 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTTTTATATGAT
TAATAAATAACCAT

Structures

Antitoxin