Detailed information of TA system TA211416

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2146363..2146838
• Replicon: chromosome
• Accession: NZ_CP080249
• Organism: Staphylococcus aureus strain NV_1

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: KZW86_RS10775
• Protein ID: WP_000387655.1
• Coordinates: 2146363..2146665 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2146714..2146838 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZW86_RS10760	2142183..2143136	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
KZW86_RS10765	2143813..2144553	-	741	WP_000185611.1	type II CAAX endopeptidase family protein	-
KZW86_RS10770	2144898..2146352	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
KZW86_RS10775	2146363..2146665	-	303	WP_000387655.1	phage holin	Toxin
-	2146714..2146838	+	125	-	-	Antitoxin
KZW86_RS10785	2146863..2146970	-	108	WP_000253687.1	putative holin-like toxin	-
KZW86_RS10790	2147204..2147503	-	300	WP_000466781.1	DUF2951 family protein	-
KZW86_RS10795	2147549..2147713	-	165	WP_000916020.1	XkdX family protein	-
KZW86_RS10800	2147706..2148095	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
KZW86_RS10805	2148095..2149561	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
KZW86_RS10810	2149561..2151471	-	1911	WP_000429548.1	hypothetical protein	-
KZW86_RS10815	2151487..2151777	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2144898..2197154	52256

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T211416 WP_000387655.1 NZ_CP080249:c2146665-2146363 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T211416 NZ_CP104858:c907918-907520 [Salmonella sp. 3C]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Nucleotide

• Length: 125 bp

>AT211416 NZ_CP080249:2146714-2146838 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin