Detailed information of TA system TA211410

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 913568..914062
• Replicon: chromosome
• Accession: NZ_CP080249
• Organism: Staphylococcus aureus strain NV_1

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A4P7P563
• Locus tag: KZW86_RS04525
• Protein ID: WP_000351119.1
• Coordinates: 913787..914062 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	913568..913707 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZW86_RS04500	912342..912494	+	153	WP_001000058.1	hypothetical protein	-
KZW86_RS04505	912540..912827	+	288	WP_001262623.1	hypothetical protein	-
KZW86_RS04510	912883..913257	+	375	WP_000340977.1	hypothetical protein	-
KZW86_RS04515	913400..913576	+	177	WP_072353918.1	type I toxin-antitoxin system toxin PepG1	-
KZW86_RS04525	913787..914062	+	276	WP_000351119.1	phage holin	Toxin
KZW86_RS04530	914049..915461	+	1413	WP_115287713.1	N-acetylmuramoyl-L-alanine amidase	-
KZW86_RS04535	915606..915758	+	153	WP_001788502.1	hypothetical protein	-
KZW86_RS04540	915829..915939	+	111	WP_000139423.1	hypothetical protein	-
KZW86_RS04545	915941..916126	+	186	WP_001286805.1	hypothetical protein	-
KZW86_RS04550	916811..916950	+	140	Protein_885	hypothetical protein	-
KZW86_RS04555	916956..917270	-	315	WP_000274029.1	hypothetical protein	-
KZW86_RS04560	917635..918675	+	1041	WP_000582326.1	CNNM domain-containing protein	-
-	913564..913738	-	175	-	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	873950..916126	42176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9975.53 Da
• Isoelectric Point: 9.8179

>T211410 WP_000351119.1 NZ_CP080249:913787-914062 [Staphylococcus aureus]
MDIGTIVRTILLIVAWINQFLAIKHISPIPVDEVFISTVVTGIVSIWTWWKNNNFTHASKKGQQKIYEVKAGIQSTGGAP
KVNGDDNNAVG

Nucleotide

• Length: 276 bp

>T211410 NZ_CP104856:c2804798-2804697 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT211410 NZ_CP080249:c913707-913568 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7P563

Antitoxin