Detailed information of TA system TA211401

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3885695..3886107
• Replicon: chromosome
• Accession: NZ_CP080247
• Organism: Escherichia sp. TM-G17TGC

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: KY274_RS18935
• Protein ID: WP_000132601.1
• Coordinates: 3885766..3886107 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3885695..3885771 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KY274_RS18925 (3882558)	3882558..3884147	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
KY274_RS18930 (3884144)	3884144..3885538	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
- (3885695)	3885695..3885771	-	77	NuclAT_14	-	Antitoxin
- (3885695)	3885695..3885771	-	77	NuclAT_14	-	Antitoxin
- (3885695)	3885695..3885771	-	77	NuclAT_14	-	Antitoxin
- (3885695)	3885695..3885771	-	77	NuclAT_14	-	Antitoxin
- (3885695)	3885695..3885771	-	77	NuclAT_15	-	Antitoxin
- (3885695)	3885695..3885771	-	77	NuclAT_15	-	Antitoxin
- (3885695)	3885695..3885771	-	77	NuclAT_15	-	Antitoxin
- (3885695)	3885695..3885771	-	77	NuclAT_15	-	Antitoxin
KY274_RS18935 (3885766)	3885766..3886107	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
KY274_RS18940 (3886269)	3886269..3887648	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
KY274_RS18945 (3887648)	3887648..3888694	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T211401 WP_000132601.1 NZ_CP080247:3885766-3886107 [Escherichia sp. TM-G17TGC]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T211401 NZ_CP104852:c78591-78286 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTCTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT211401 NZ_CP080247:c3885771-3885695 [Escherichia sp. TM-G17TGC]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin