Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 2700937..2701625 Replicon chromosome
Accession NC_006512
Organism Idiomarina loihiensis L2TR

Toxin (Protein)


Gene name yafO Uniprot ID Q5QV98
Locus tag IL_RS12935 Protein ID WP_011235748.1
Coordinates 2700937..2701335 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID Q5QV97
Locus tag IL_RS12940 Protein ID WP_011235749.1
Coordinates 2701332..2701625 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL_RS12895 2696056..2696286 + 231 WP_011235740.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
IL_RS12900 2696283..2696732 + 450 WP_011235741.1 type II toxin-antitoxin system VapC family toxin -
IL_RS12905 2696747..2697454 - 708 WP_011235742.1 ZIP family metal transporter -
IL_RS12910 2697457..2698737 - 1281 WP_011235743.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
IL_RS12915 2698942..2699235 + 294 WP_011235744.1 type II toxin-antitoxin system RelE/ParE family toxin -
IL_RS12920 2699247..2699570 + 324 WP_011235745.1 HigA family addiction module antidote protein -
IL_RS12925 2699592..2700080 - 489 WP_011235746.1 hypothetical protein -
IL_RS12930 2700272..2700940 + 669 WP_011235747.1 hypothetical protein -
IL_RS12935 2700937..2701335 - 399 WP_011235748.1 type II toxin-antitoxin system YafO family toxin Toxin
IL_RS12940 2701332..2701625 - 294 WP_011235749.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
IL_RS12945 2701719..2702861 - 1143 WP_011235750.1 alpha/beta hydrolase -
IL_RS12950 2702992..2703507 + 516 WP_011235751.1 DNA mismatch endonuclease Vsr -
IL_RS12955 2703805..2705064 + 1260 WP_011235752.1 DNA (cytosine-5-)-methyltransferase -
IL_RS12960 2705042..2706367 - 1326 WP_011235753.1 MspI family type II restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15407.84 Da        Isoelectric Point: 7.0384

>T21139 WP_011235748.1 NC_006512:c2701335-2700937 [Idiomarina loihiensis L2TR]
VIRVFKSKQIRQQLTDIELDALVKDFKRYKSGEGVPDLFGRDERYDHPDTFPVLRDNEVMHLHLQDPDEPWPLHCIQFAK
KSDTHLVYCPAAMTPNCYLLMIILDPPAHNKAWSSAVMLPLGIMAEKFRNRY

Download         Length: 399 bp

>T21139 NC_006512:c2701335-2700937 [Idiomarina loihiensis L2TR]
GTGATTCGGGTTTTTAAGAGCAAACAGATTCGTCAGCAATTAACTGATATTGAACTGGATGCATTAGTAAAAGACTTTAA
GCGCTATAAAAGTGGCGAGGGCGTGCCTGACCTGTTCGGGCGCGATGAACGCTATGATCATCCAGATACCTTCCCGGTTC
TTCGTGACAATGAAGTAATGCATTTGCATCTACAAGATCCCGATGAGCCTTGGCCTTTGCATTGCATTCAGTTTGCTAAG
AAAAGTGATACGCACTTAGTCTATTGTCCGGCAGCTATGACGCCCAACTGCTATTTGCTTATGATAATTCTTGATCCTCC
TGCTCACAACAAAGCATGGAGCAGTGCGGTTATGCTACCCCTAGGAATAATGGCAGAAAAATTCCGTAATCGGTATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10759.25 Da        Isoelectric Point: 4.9001

>AT21139 WP_011235749.1 NC_006512:c2701625-2701332 [Idiomarina loihiensis L2TR]
MNTQTILAEKTVSASDVRKHPCQYFEAEPVAVLSHNKTAGYMVGAELFEAMVRQLEACNPKVESLFRPTTARLKAISAEA
EKLLAEAKKSDLDDFEE

Download         Length: 294 bp

>AT21139 NC_006512:c2701625-2701332 [Idiomarina loihiensis L2TR]
ATGAACACACAAACTATATTGGCTGAAAAAACGGTATCTGCCAGTGACGTGCGCAAACACCCCTGCCAGTATTTTGAAGC
TGAGCCTGTGGCGGTACTTTCCCACAATAAAACCGCTGGTTACATGGTAGGTGCTGAGTTATTTGAAGCTATGGTACGCC
AGTTGGAAGCCTGTAACCCTAAAGTAGAGTCCCTTTTTAGGCCGACGACAGCGCGGCTAAAGGCTATTAGTGCCGAAGCA
GAGAAGCTTTTAGCTGAAGCGAAAAAGTCTGATCTGGATGACTTTGAAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5QV98

Antitoxin

Source ID Structure
AlphaFold DB A0A432YT68

References