Detailed information of TA system TA021138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2698942..2699570
• Replicon: chromosome
• Accession: NC_006512
• Organism: Idiomarina loihiensis L2TR

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q5QV89
• Locus tag: IL_RS12915
• Protein ID: WP_011235744.1
• Coordinates: 2698942..2699235 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IL_RS12920
• Protein ID: WP_011235745.1
• Coordinates: 2699247..2699570 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL_RS12890	2695273..2695929	-	657	WP_011235739.1	epoxyqueuosine reductase QueH	-
IL_RS12895	2696056..2696286	+	231	WP_011235740.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
IL_RS12900	2696283..2696732	+	450	WP_011235741.1	type II toxin-antitoxin system VapC family toxin	-
IL_RS12905	2696747..2697454	-	708	WP_011235742.1	ZIP family metal transporter	-
IL_RS12910	2697457..2698737	-	1281	WP_011235743.1	deoxyguanosinetriphosphate triphosphohydrolase family protein	-
IL_RS12915	2698942..2699235	+	294	WP_011235744.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IL_RS12920	2699247..2699570	+	324	WP_011235745.1	HigA family addiction module antidote protein	Antitoxin
IL_RS12925	2699592..2700080	-	489	WP_011235746.1	hypothetical protein	-
IL_RS12930	2700272..2700940	+	669	WP_011235747.1	hypothetical protein	-
IL_RS12935	2700937..2701335	-	399	WP_011235748.1	type II toxin-antitoxin system YafO family toxin	-
IL_RS12940	2701332..2701625	-	294	WP_011235749.1	type I toxin-antitoxin system antitoxin YafN	-
IL_RS12945	2701719..2702861	-	1143	WP_011235750.1	alpha/beta hydrolase	-
IL_RS12950	2702992..2703507	+	516	WP_011235751.1	DNA mismatch endonuclease Vsr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-70)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11509.13 Da
• Isoelectric Point: 7.2739

>T21138 WP_011235744.1 NC_006512:2698942-2699235 [Idiomarina loihiensis L2TR]
MAVTFRDDWLERFYEDDISHKKIPKIIKGALFRKLEILDAATQESDLRVPPGNRFEYLKGKLSGYCSIRVNKQYRLIFHW
EDGIAQDTYLDPHVYQS

Nucleotide

• Length: 294 bp

>T21138 NC_006512:2698942-2699235 [Idiomarina loihiensis L2TR]
ATGGCCGTTACATTCAGGGACGATTGGCTAGAACGATTCTACGAAGATGATATCAGCCACAAGAAAATACCGAAGATCAT
CAAAGGAGCGCTCTTCAGGAAGCTCGAAATTTTGGATGCTGCAACGCAGGAGTCAGATTTAAGGGTTCCCCCAGGTAATC
GCTTCGAATATTTAAAAGGAAAACTTTCGGGGTATTGTTCTATCCGGGTTAACAAACAGTATCGACTTATTTTCCACTGG
GAAGACGGTATCGCCCAAGATACATACCTGGATCCACACGTTTACCAAAGTTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12351.33 Da
• Isoelectric Point: 10.0417

>AT21138 WP_011235745.1 NC_006512:2699247-2699570 [Idiomarina loihiensis L2TR]
MRDTKRRPVSVGQMLITEFLEPMNIEIKELADAMRVHRNTLSRIVHDKGALTAPMAIKLAAALGNTPEFWLNIQHAVEIW
DVRHRAYEQEAENVKRLKPHAKPYQQA

Nucleotide

• Length: 324 bp

>AT21138 NC_006512:2699247-2699570 [Idiomarina loihiensis L2TR]
ATGAGAGATACAAAACGTCGCCCGGTATCCGTTGGCCAGATGCTAATAACCGAGTTTCTTGAACCGATGAACATTGAAAT
AAAAGAGCTCGCTGATGCTATGAGAGTACACAGAAACACGCTCAGCCGAATTGTTCATGACAAAGGAGCCTTGACCGCAC
CTATGGCTATTAAATTAGCTGCCGCTTTGGGTAACACCCCGGAGTTCTGGTTGAACATTCAGCACGCCGTCGAAATCTGG
GACGTACGCCACCGGGCATACGAACAAGAAGCTGAAAACGTAAAGCGCTTGAAACCTCACGCTAAGCCTTATCAGCAGGC
TTGA

Structures

Toxin

• AlphaFold DB: Q5QV89