211379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 715187..715880 Replicon chromosome
Accession NZ_CP080247
Organism Escherichia sp. TM-G17TGC

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KY274_RS03475 Protein ID WP_000415584.1
Coordinates 715187..715483 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KY274_RS03480 Protein ID WP_000650107.1
Coordinates 715485..715880 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY274_RS03440 (710275) 710275..710589 - 315 WP_000958598.1 putative quinol monooxygenase -
KY274_RS03445 (710620) 710620..711201 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KY274_RS03450 (711520) 711520..711852 + 333 WP_000917684.1 DUF2645 family protein -
KY274_RS03455 (711898) 711898..713247 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KY274_RS03460 (713244) 713244..713903 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
KY274_RS03465 (714055) 714055..714447 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KY274_RS03470 (714500) 714500..714982 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KY274_RS03475 (715187) 715187..715483 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KY274_RS03480 (715485) 715485..715880 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KY274_RS03485 (716013) 716013..717620 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KY274_RS03490 (717758) 717758..720016 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T211379 WP_000415584.1 NZ_CP080247:715187-715483 [Escherichia sp. TM-G17TGC]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T211379 NZ_CP104849:36380-36685 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT211379 WP_000650107.1 NZ_CP080247:715485-715880 [Escherichia sp. TM-G17TGC]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT211379 NZ_CP104849:36160-36378 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References