Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605931..606730 Replicon chromosome
Accession NZ_CP080247
Organism Escherichia sp. TM-G17TGC

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag KY274_RS02940 Protein ID WP_000347273.1
Coordinates 605931..606395 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag KY274_RS02945 Protein ID WP_001307405.1
Coordinates 606395..606730 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY274_RS02915 (602107) 602107..602664 - 558 Protein_572 amidohydrolase family protein -
KY274_RS02920 (602660) 602660..603031 - 372 Protein_573 PTS sugar transporter subunit IIC -
KY274_RS02925 (603042) 603042..603515 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
KY274_RS02930 (603538) 603538..604818 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
KY274_RS02935 (605067) 605067..605876 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KY274_RS02940 (605931) 605931..606395 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KY274_RS02945 (606395) 606395..606730 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KY274_RS02950 (606879) 606879..608450 - 1572 WP_001273747.1 galactarate dehydratase -
KY274_RS02955 (608825) 608825..610159 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
KY274_RS02960 (610175) 610175..610945 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T211377 WP_000347273.1 NZ_CP080247:c606395-605931 [Escherichia sp. TM-G17TGC]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T211377 NZ_CP104848:c4854615-4854304 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT211377 WP_001307405.1 NZ_CP080247:c606730-606395 [Escherichia sp. TM-G17TGC]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT211377 NZ_CP104848:c4854303-4854013 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References