Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
Location | 4300822..4301516 | Replicon | chromosome |
Accession | NZ_CP080235 | ||
Organism | Escherichia coli O139:H1 strain W13-16 |
Toxin (Protein)
Gene name | yafO | Uniprot ID | A0A0D8WHS4 |
Locus tag | KZW92_RS21020 | Protein ID | WP_001521903.1 |
Coordinates | 4301118..4301516 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | yafN | Uniprot ID | L4JHF0 |
Locus tag | KZW92_RS21015 | Protein ID | WP_000554755.1 |
Coordinates | 4300822..4301115 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZW92_RS20990 (4296443) | 4296443..4296799 | - | 357 | WP_001030484.1 | type II toxin-antitoxin system HicB family antitoxin | - |
KZW92_RS20995 (4296792) | 4296792..4297070 | - | 279 | WP_000598760.1 | type II toxin-antitoxin system HicA family toxin | - |
KZW92_RS21000 (4297175) | 4297175..4298887 | - | 1713 | Protein_4113 | flagellar biosynthesis protein FlhA | - |
KZW92_RS21005 (4298859) | 4298859..4299644 | + | 786 | WP_074150236.1 | putative lateral flagellar export/assembly protein LafU | - |
KZW92_RS21010 (4299715) | 4299715..4300770 | + | 1056 | WP_001226166.1 | DNA polymerase IV | - |
KZW92_RS21015 (4300822) | 4300822..4301115 | + | 294 | WP_000554755.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
KZW92_RS21020 (4301118) | 4301118..4301516 | + | 399 | WP_001521903.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
KZW92_RS21025 (4301526) | 4301526..4301978 | + | 453 | WP_001059858.1 | GNAT family N-acetyltransferase | - |
KZW92_RS21030 (4302297) | 4302297..4303436 | + | 1140 | WP_063085369.1 | RNA ligase RtcB family protein | - |
KZW92_RS21035 (4303433) | 4303433..4304047 | + | 615 | WP_000602129.1 | peptide chain release factor H | - |
KZW92_RS21040 (4304109) | 4304109..4304618 | + | 510 | WP_063085380.1 | metal-dependent hydrolase | - |
KZW92_RS21045 (4304635) | 4304635..4304916 | - | 282 | WP_077881290.1 | hypothetical protein | - |
KZW92_RS21050 (4304925) | 4304925..4306382 | - | 1458 | WP_001293009.1 | cytosol nonspecific dipeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15471.88 Da Isoelectric Point: 8.0949
>T211332 WP_001521903.1 NZ_CP080235:4301118-4301516 [Escherichia coli O139:H1]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGILPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGILPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T211332 NZ_CP104846:186695-186802 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11235.78 Da Isoelectric Point: 5.2170
>AT211332 WP_000554755.1 NZ_CP080235:4300822-4301115 [Escherichia coli O139:H1]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKLVKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKLVKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT211332 NZ_CP104846:c186638-186581 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D8WHS4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G9H5 |